Persistent Crimean-Congo hemorrhagic fever virus infection in the testes and within granulomas of non-human primates with latent tuberculosis.

Autor: Smith DR; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, Maryland, United States of America., Shoemaker CJ; Diagnostic Systems Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, Maryland, United States of America., Zeng X; Pathology Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, Maryland, United States of America., Garrison AR; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, Maryland, United States of America., Golden JW; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, Maryland, United States of America., Schellhase CW; Pathology Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, Maryland, United States of America., Pratt W; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, Maryland, United States of America., Rossi F; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, Maryland, United States of America., Fitzpatrick CJ; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, Maryland, United States of America., Shamblin J; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, Maryland, United States of America., Kimmel A; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, Maryland, United States of America., Zelko J; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, Maryland, United States of America., Flusin O; Diagnostic Systems Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, Maryland, United States of America., Koehler JW; Diagnostic Systems Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, Maryland, United States of America., Liu J; Pathology Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, Maryland, United States of America., Coffin KM; Pathology Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, Maryland, United States of America., Ricks KM; Diagnostic Systems Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, Maryland, United States of America., Voorhees MA; Diagnostic Systems Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, Maryland, United States of America., Schoepp RJ; Diagnostic Systems Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, Maryland, United States of America., Schmaljohn CS; Headquarters Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, Maryland, United States of America.
Jazyk: angličtina
Zdroj: PLoS pathogens [PLoS Pathog] 2019 Sep 26; Vol. 15 (9), pp. e1008050. Date of Electronic Publication: 2019 Sep 26 (Print Publication: 2019).
DOI: 10.1371/journal.ppat.1008050
Abstrakt: Crimean-Congo hemorrhagic fever (CCHF) is the most medically important tick-borne viral disease of humans and tuberculosis is the leading cause of death worldwide by a bacterial pathogen. These two diseases overlap geographically, however, concurrent infection of CCHF virus (CCHFV) with mycobacterial infection has not been assessed nor has the ability of virus to persist and cause long-term sequela in a primate model. In this study, we compared the disease progression of two diverse strains of CCHFV in the recently described cynomolgus macaque model. All animals demonstrated signs of clinical illness, viremia, significant changes in clinical chemistry and hematology values, and serum cytokine profiles consistent with CCHF in humans. The European and Asian CCHFV strains caused very similar disease profiles in monkeys, which demonstrates that medical countermeasures can be evaluated in this animal model against multiple CCHFV strains. We identified evidence of CCHFV persistence in the testes of three male monkeys that survived infection. Furthermore, the histopathology unexpectedly revealed that six additional animals had evidence of a latent mycobacterial infection with granulomatous lesions. Interestingly, CCHFV persisted within the granulomas of two animals. This study is the first to demonstrate the persistence of CCHFV in the testes and within the granulomas of non-human primates with concurrent latent tuberculosis. Our results have important public health implications in overlapping endemic regions for these emerging pathogens.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje