| Autor: |
Levinn CM; Department of Chemistry and Biochemistry, Materials Science Institute, Institute of Molecular Biology, University of Oregon, Eugene, Oregon., Cerda MM; Department of Chemistry and Biochemistry, Materials Science Institute, Institute of Molecular Biology, University of Oregon, Eugene, Oregon., Pluth MD; Department of Chemistry and Biochemistry, Materials Science Institute, Institute of Molecular Biology, University of Oregon, Eugene, Oregon. |
| Jazyk: |
angličtina |
| Zdroj: |
Antioxidants & redox signaling [Antioxid Redox Signal] 2020 Jan 10; Vol. 32 (2), pp. 96-109. Date of Electronic Publication: 2019 Oct 29. |
| DOI: |
10.1089/ars.2019.7841 |
| Abstrakt: |
Significance: Hydrogen sulfide (H 2 S) is an important biological signaling molecule involved in many physiological processes. These diverse roles have led researchers to develop contemporary methods to deliver H 2 S under physiologically relevant conditions and in response to various stimuli. Recent Advances: Different small-molecule donors have been developed that release H 2 S under various conditions. Key examples include donors activated in response to hydrolysis, to endogenous species, such as thiols, reactive oxygen species, and enzymes, and to external stimuli, such as photoactivation and bio-orthogonal chemistry. In addition, an alternative approach to release H 2 S has utilized the catalyzed hydrolysis of carbonyl sulfide (COS) by carbonic anhydrase to generate libraries of activatable COS-based H 2 S donors. Critical Issues: Small-molecule H 2 S donors provide important research and pharmacological tools to perturb H 2 S levels. Key needs, both in the development and in the use of such donors, include access to new donors that respond to specific stimuli as well as donors with well-defined control compounds that allow for clear delineation of the impact of H 2 S delivery from other donor byproducts. Future Directions: The abundance of reported small-molecule H 2 S donors provides biologists and physiologists with a chemical toolbox to ask key biological questions and to develop H 2 S-related therapeutic interventions. Further investigation into different releasing efficiencies in biological contexts and a clear understanding of biological responses to donors that release H 2 S gradually ( e.g. , hours to days) versus donors that generate H 2 S quickly ( e.g. , seconds to minutes) is needed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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