Bacillus coagulans GBI-30, 6068 decreases upper respiratory and gastrointestinal tract symptoms in healthy Mexican scholar-aged children by modulating immune-related proteins.

Autor: Anaya-Loyola MA; Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Querétaro 76230, Mexico., Enciso-Moreno JA; Unidad de Investigación Biomédica de Zacatecas, IMSS, Zacatecas 98000, Mexico., López-Ramos JE; Unidad de Investigación Biomédica de Zacatecas, IMSS, Zacatecas 98000, Mexico., García-Marín G; Facultad de Química, Universidad Autónoma de Querétaro, Querétaro 76010, Mexico., Orozco Álvarez MY; Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Querétaro 76230, Mexico., Vega-García AM; Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Querétaro 76230, Mexico., Mosqueda J; Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Querétaro 76230, Mexico., García-Gutiérrez DG; Facultad de Química, Universidad Autónoma de Querétaro, Querétaro 76010, Mexico., Keller D; Keller Consulting Group, Beachwood, OH, USA., Pérez-Ramírez IF; Facultad de Química, Universidad Autónoma de Querétaro, Querétaro 76010, Mexico. Electronic address: iza.perez@uaq.mx.
Jazyk: angličtina
Zdroj: Food research international (Ottawa, Ont.) [Food Res Int] 2019 Nov; Vol. 125, pp. 108567. Date of Electronic Publication: 2019 Jul 21.
DOI: 10.1016/j.foodres.2019.108567
Abstrakt: This randomized, double-blind, parallel and placebo-controlled study aimed to evaluate the effect of Bacillus coagulans GBI-30, 6086® probiotic (GanedenBC 30 ®) against upper respiratory tract infections (URTI) and gastrointestinal tract infections (GITI) in eighty healthy school-aged children (6-8 years old). The participants received daily a sachet containing either GanedenBC 30 (1 × 10 9 colony-forming units) or placebo (maltodextrin) for three months. GanedenBC 30 significantly decreased the incidence of URTI symptoms including nasal congestion, bloody nasal mucus, itchy nose, and hoarseness. The duration of the URTI-associated symptoms of hoarseness, headache, red eyes, and fatigue was also decreased. GanedenBC 30 supplementation also significantly reduced the incidence rate of flatulence. These beneficial effects were associated with the modulation of serum TNFα, CD163, G-CSF, ICAM-1, IL-6, IL-8, MCP-2, RAGE, uPAR, and PF4. Therefore, probiotic B. coagulans GBI-30, 6086 modulated immune-related proteins in healthy children, decreasing several URTI and GITI symptoms, thus, this functional ingredient may contribute to a healthier lifestyle.
(Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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