Selective activation of serotoninergic dorsal raphe neurons facilitates sleep through anxiolysis.

Autor:	Venner A; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA.; Division of Sleep Medicine, Harvard Medical School, Boston, MA., Broadhurst RY; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA.; Division of Sleep Medicine, Harvard Medical School, Boston, MA., Sohn LT; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA.; Division of Sleep Medicine, Harvard Medical School, Boston, MA., Todd WD; Department of Zoology and Physiology, University of Wyoming, Laramie, WY.; Program in Neuroscience, University of Wyoming, Laramie, WY., Fuller PM; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA.; Division of Sleep Medicine, Harvard Medical School, Boston, MA.
Jazyk:	angličtina
Zdroj:	Sleep [Sleep] 2020 Feb 13; Vol. 43 (2).
DOI:	10.1093/sleep/zsz231
Abstrakt:	A role for the brain's serotoninergic (5HT) system in the regulation of sleep and wakefulness has been long suggested. Yet, previous studies employing pharmacological, lesion and genetically driven approaches have produced inconsistent findings, leaving 5HT's role in sleep-wake regulation incompletely understood. Here we sought to define the specific contribution of 5HT neurons within the dorsal raphe nucleus (DRN5HT) to sleep and arousal control. To do this, we employed a chemogenetic strategy to selectively and acutely activate DRN5HT neurons and monitored sleep-wake using electroencephalogram recordings. We additionally assessed indices of anxiety using the open field and elevated plus maze behavioral tests and employed telemetric-based recordings to test effects of acute DRN5HT activation on body temperature and locomotor activity. Our findings indicate that the DRN5HT cell population may not modulate sleep-wake per se, but rather that its activation has apparent anxiolytic properties, suggesting the more nuanced view that DRN5HT neurons are sleep permissive under circumstances that produce anxiety or stress. (© Sleep Research Society 2019. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.)
Databáze:	MEDLINE
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