Body size and dietary risk factors for aggressive prostate cancer: a case-control study.

Autor: Pal M; Karolinska Institute, Stockholm, Sweden. palmikaela@gmail.com.; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia. palmikaela@gmail.com., Hodge AM; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC, Australia., Papa N; Department of Surgery, Austin Health, The University of Melbourne, Melbourne, VIC, Australia., MacInnis RJ; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC, Australia., Bassett JK; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia., Bolton D; Department of Surgery, Austin Health, The University of Melbourne, Melbourne, VIC, Australia.; Olivia Newton-John Cancer and Wellness Centre, Austin Health, Heidelberg, VIC, Australia., Davis ID; Monash University, Melbourne, VIC, Australia.; Eastern Health, Box Hill, VIC, Australia., Millar J; Alfred Health Radiation Oncology, Alfred Hospital, Melbourne, VIC, Australia.; Department of Surgery, Central Clinical School, Monash University, The Alfred Centre, Melbourne, VIC, Australia., English DR; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC, Australia., Hopper JL; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC, Australia., Severi G; Centre de Recherche en Épidémiologie et Santé des Populations (CESP, Inserm U1018), Facultés de Médecine, Université Paris-Saclay, UPS UVSQ, Gustave Roussy, Villejuif, France., Southey MC; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.; Genetic Epidemiology Laboratory, Department of Clinical Pathology, University of Melbourne, Parkville, VIC, Australia., Milne RL; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC, Australia.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia., Giles GG; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC, Australia.
Jazyk: angličtina
Zdroj: Cancer causes & control : CCC [Cancer Causes Control] 2019 Dec; Vol. 30 (12), pp. 1301-1312. Date of Electronic Publication: 2019 Sep 24.
DOI: 10.1007/s10552-019-01234-7
Abstrakt: Purpose: Diet and body size may affect the risk of aggressive prostate cancer (APC), but current evidence is inconclusive.
Methods: A case-control study was conducted in men under 75 years of age recruited from urology practices in Victoria, Australia; 1,254 with APC and 818 controls for whom the presence of prostate cancer had been excluded by biopsy. Dietary intakes were assessed using a validated food frequency questionnaire. Multivariable unconditional logistic regression estimated odds ratios and confidence intervals for hypothesized risk factors, adjusting for age, family history of prostate cancer, country of birth, socioeconomic status, smoking, and other dietary factors.
Results: Positive associations with APC (odds ratio, 95% confidence intervals, highest vs. lowest category or quintile) were observed for body mass index (1.34, 1.02-1.78, P trend  = 0.04), and trouser size (1.54, 1.17-2.04, P trend  = 0.001). Intakes of milk and all dairy products were inversely associated with APC risk (0.71, 9.53-0.96, P trend  = 0.05, and 0.64, 0.48-0.87, P trend  = 0.012, respectively), but there was little evidence of an association with other dietary variables (P trend  > 0.05).
Conclusions: We confirmed previous evidence for a positive association between body size and risk of APC, and suggest that consumption of dairy products, and milk more specifically, is inversely associated with risk.
Databáze: MEDLINE
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