| Autor: |
Avelar Rodriguez D; Pediatric Gastroenterology and Nutrition Unit, National Institute of Pediatrics, Mexico City, Mexico., Ryan PM; School of Medicine, University College Cork, Cork, Ireland., Toro Monjaraz EM; Pediatric Gastroenterology and Nutrition Unit, National Institute of Pediatrics, Mexico City, Mexico., Ramirez Mayans JA; Pediatric Gastroenterology and Nutrition Unit, National Institute of Pediatrics, Mexico City, Mexico., Quigley EM; Lynda K. and David M. Underwood Center for Digestive Disorders, Houston Methodist Hospital, Houston, TX, United States. |
| Jazyk: |
angličtina |
| Zdroj: |
Frontiers in pediatrics [Front Pediatr] 2019 Sep 04; Vol. 7, pp. 363. Date of Electronic Publication: 2019 Sep 04 (Print Publication: 2019). |
| DOI: |
10.3389/fped.2019.00363 |
| Abstrakt: |
Small intestinal bacterial overgrowth (SIBO) is a heterogenous and poorly understood entity characterised by an excessive growth of select microorganisms within the small intestine. This excessive bacterial biomass, in turn, disrupts host physiology in a myriad of ways, leading to gastrointestinal and non-gastrointestinal symptoms and complications. SIBO is a common cause of non-specific gastrointestinal symptoms in children, such as chronic abdominal pain, abdominal distention, diarrhoea, and flatulence, amongst others. In addition, it has recently been implicated in the pathophysiology of stunting, a disease that affects millions of children worldwide. Risk factors such as acid-suppressive therapies, alterations in gastrointestinal motility and anatomy, as well as impoverished conditions, have been shown to predispose children to SIBO. SIBO can be diagnosed via culture-dependant or culture-independent approaches. SIBO's epidemiology is limited due to the lack of uniformity and consensus of its diagnostic criteria, as well as the paucity of literature available. Antibiotics remain the first-line treatment option for SIBO, although emerging modalities such as probiotics and diet manipulation could also have a role. Herein, we present a state-of-the-art-review which aims to comprehensively outline the most current information on SIBO in children, with particular emphasis on the gut microbiota. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
