Electroactive nanofibers mats based on poly(l-lactic acid)/poly(ortho-ethoxyaniline) blends for biological applications.

Autor: Lemos HG; Center for Engineering, Modeling and Applied Social Sciences, Federal University of ABC (UFABC), Santo André, São Paulo 09210-580, Brazil., Silva LMGD; Center for Engineering, Modeling and Applied Social Sciences, Federal University of ABC (UFABC), Santo André, São Paulo 09210-580, Brazil., Ambrosio FN; Center for Engineering, Modeling and Applied Social Sciences, Federal University of ABC (UFABC), Santo André, São Paulo 09210-580, Brazil., Lombello CB; Center for Engineering, Modeling and Applied Social Sciences, Federal University of ABC (UFABC), Santo André, São Paulo 09210-580, Brazil; Nanomedicine Research Unit (NANOMED), Federal University of ABC (UFABC), Santo André, São Paulo 09210-580, Brazil., Moreira JC; Center for Engineering, Modeling and Applied Social Sciences, Federal University of ABC (UFABC), Santo André, São Paulo 09210-580, Brazil., Venancio EC; Center for Engineering, Modeling and Applied Social Sciences, Federal University of ABC (UFABC), Santo André, São Paulo 09210-580, Brazil. Electronic address: everaldo.venancio@ufabc.edu.br.
Jazyk: angličtina
Zdroj: Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2019 Dec; Vol. 105, pp. 110045. Date of Electronic Publication: 2019 Aug 01.
DOI: 10.1016/j.msec.2019.110045
Abstrakt: The combination of scaffolds with desirable topographic characteristics and the use of electrical stimulus consist of a strategy to repair and regenerate tissues. An interesting approach to obtain electroactive scaffolds with the aforementioned features comprises on the use of conducting polymers which can be blended with other biocompatible polymers. In this work, poly(l-lactic acid) (PLLA) and poly(ortho-ethoxyaniline) (POEA) were synthesized and PLLA/POEA mats were prepared for the first time by electrospinning technique. Topographic characterization of PLLA/POEA showed a tunable mean diameter of the nanofibers by changing the electrospinning parameters. The presence of POEA into the blend was confirmed by X-ray photoelectron and Fourier-transform infrared spectroscopy analyses. Differential scanning calorimetry curves of PLLA/POEA exhibited shift positions of T c and absence of the exothermic peak related to the characteristic isomerization process of POEA at high temperatures. The thermal analysis results indicate a favored miscibility between the polymers which is likely resulted from the strong interaction between polymers functionalities. The homogenous distribution of POEA chains throughout the scaffold rendered redox reversibility property for the mats. Biocompatibility results showed non-cytotoxic features for PLLA/POEA, attesting this novel system as a promising candidate for biological applications.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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