Exploring a Ring-Closing Metathesis Approach to the Archazolid Macrocycle.
| Autor: | King BR; Department of Chemistry, Western Washington University, Bellingham, WA 98225., Swick SM; Department of Chemistry, Western Washington University, Bellingham, WA 98225., Schaefer SL; Department of Chemistry, Western Washington University, Bellingham, WA 98225., Welch JR; Department of Chemistry, Western Washington University, Bellingham, WA 98225., Hunter EF; Department of Chemistry, Western Washington University, Bellingham, WA 98225., O'Neil GW; Department of Chemistry, Western Washington University, Bellingham, WA 98225. |
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| Jazyk: | angličtina |
| Zdroj: | Synthesis [Synthesis (Stuttg)] 2014 Nov; Vol. 46 (21), pp. 2927-2936. Date of Electronic Publication: 2014 Aug 15. |
| DOI: | 10.1055/s-0034-1379003 |
| Abstrakt: | The synthesis of a new "eastern domain" of a proposed dihydroarchazolid analogue is described along with initial results from attempted macrocyclization by RCM. This work has revealed a competing backbiting process that may be preventable by alcohol functionalization and installation of a metathesis relay. |
| Databáze: | MEDLINE |
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