Disinhibition in Frontotemporal Dementia and Alzheimer's Disease: A Neuropsychological and Behavioural Investigation.

Autor:	Mariano LI; Programa de Pós-Graduação em Neurociências, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais (MG) 31270-901, Brazil.; Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina da UFMG, Belo Horizonte, MG 30130-100, Brazil., O'Callaghan C; Brain and Mind Research Institute, University of Sydney, Sydney 2050, Australia.; Department of Psychiatry, University of Cambridge, Cambridge CB2 0SZ, UK., Guimarães HC; Programa de Pós-Graduação em Neurociências, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais (MG) 31270-901, Brazil., Gambogi LB; Programa de Pós-Graduação em Neurociências, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais (MG) 31270-901, Brazil., da Silva TBL; Cognitive Behavior Neurology Group (GNCC), Neurology Department, University of São Paulo, São Paulo 05403-000, Brazil.; Gerontology, School of Arts, Sciences and Humanities, University of São Paulo, São Paulo 03828-000, Brazil., Yassuda MS; Cognitive Behavior Neurology Group (GNCC), Neurology Department, University of São Paulo, São Paulo 05403-000, Brazil.; Gerontology, School of Arts, Sciences and Humanities, University of São Paulo, São Paulo 03828-000, Brazil., Amaral JS; Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina da UFMG, Belo Horizonte, MG 30130-100, Brazil., Caramelli P; Departamento de Clínica Médica, Faculdade de Medicina da UFMG, Belo Horizonte, MG 30130-100, Brazil., Hornberger M; Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK., Teixeira AL; Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina da UFMG, Belo Horizonte, MG 30130-100, Brazil.; Neuropsychiatry Program, Department of Psychiatry & Behavioral Sciences, UTHealth Houston, Houston, TX 77030, USA., de Souza LC; Programa de Pós-Graduação em Neurociências, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais (MG) 31270-901, Brazil.; Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina da UFMG, Belo Horizonte, MG 30130-100, Brazil.; Departamento de Clínica Médica, Faculdade de Medicina da UFMG, Belo Horizonte, MG 30130-100, Brazil.
Jazyk:	angličtina
Zdroj:	Journal of the International Neuropsychological Society : JINS [J Int Neuropsychol Soc] 2020 Feb; Vol. 26 (2), pp. 163-171. Date of Electronic Publication: 2019 Sep 23.
DOI:	10.1017/S1355617719000973
Abstrakt:	Objective: Cognitive tests of inhibitory control show variable results for the differential diagnosis between behavioural variant of Frontotemporal Dementia (bvFTD) and Alzheimer's disease (AD). We compared the diagnostic accuracies of tests of inhibitory control and of a behavioural questionnaire, to distinguish bvFTD from AD. Methods: Three groups of participants were enrolled: 27 bvFTD patients, 25 AD patients, and 24 healthy controls. Groups were matched for gender, education, and socio-economic level. Participants underwent a comprehensive neuropsychological assessment of inhibitory control, including Hayling Test, Stroop, the Five Digits Test (FDT) and the Delay Discounting Task (DDT). Caregivers completed the Barratt Impulsiveness Scale 11th version (BIS-11). Results: bvFTD and AD groups showed no difference in the tasks of inhibitory control, while the caregiver questionnaire revealed that bvFTD patients were significantly more impulsive (BIS-11: bvFTD 76.1+9.5, AD 62.9+13, p < .001). Conclusions: Neuropsychological tests of inhibitory control failed to distinguish bvFTD from AD. On the contrary, impulsivity caregiver-completed questionnaire provided good distinction between bvFTD and AD. These results highlight the current limits of cognitive measures of inhibitory control for the differential diagnosis between bvFTD and AD, whereas questionnaire information appears more reliable and in line with clinical diagnostics.
Databáze:	MEDLINE
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