Monocyte-derived dendritic cells in malaria.

Autor: Hirako IC; Fundação Oswaldo Cruz - Minas, 30190-002 Belo Horizonte, MG, Brazil; University of Massachusetts Medical School, 01605 Worcester, MA, United States., Assis PA; University of Massachusetts Medical School, 01605 Worcester, MA, United States., Galvão-Filho B; Fundação Oswaldo Cruz - Minas, 30190-002 Belo Horizonte, MG, Brazil., Luster AD; Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States., Antonelli LR; Fundação Oswaldo Cruz - Minas, 30190-002 Belo Horizonte, MG, Brazil., Gazzinelli RT; Fundação Oswaldo Cruz - Minas, 30190-002 Belo Horizonte, MG, Brazil; University of Massachusetts Medical School, 01605 Worcester, MA, United States; Plataforma de Medicina Translacional, Fundação Oswaldo Cruz, 14049-900, Ribeirão Preto, SP, Brazil. Electronic address: ricardo.gazzinelli@umassmed.edu.
Jazyk: angličtina
Zdroj: Current opinion in microbiology [Curr Opin Microbiol] 2019 Dec; Vol. 52, pp. 139-150. Date of Electronic Publication: 2019 Sep 19.
DOI: 10.1016/j.mib.2019.08.002
Abstrakt: The pathogenesis of malaria is a multifactorial syndrome associated with a deleterious inflammatory response that is responsible for many of the clinical manifestations. While dendritic cells (DCs) play a critical role in initiating acquired immunity and host resistance to infection, they also play a pathogenic role in inflammatory diseases. In our recent studies, we found in different rodent malaria models that the monocyte-derived DCs (MO-DCs) become, transiently, a main DC population in spleens and inflamed non-lymphoid organs. These studies suggest that acute infection with Plasmodium berghei promotes the differentiation of splenic monocytes into inflammatory monocytes (iMOs) and thereafter into MO-DCs that play a pathogenic role by promoting inflammation and tissue damage. The recruitment of MO-DCs to the lungs and brain are dependent on expression of CCR4 and CCR5, respectively, and expression of respective chemokine ligands in each organ. Once they reach the target organ the MO-DCs produce the CXCR3 ligands (CXCL9 and CXCL10), recruit CD8 + T cells, and produce toxic metabolites that play an important role in the development of experimental cerebral malaria (ECM) and acute respiratory distress syndrome (ARDS).
(Copyright © 2019 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: