| Autor: |
Montes Castillo MC; Endocrinology and Nutrition, Jaen University Hospital, Av. Ejército Español, sn, Jaén, Spain. cristinamontescastillo86@gmail.com.; Endocrinology and Nutrition, La Paz University Hospital, Madrid, Spain. cristinamontescastillo86@gmail.com., Martínez Ramírez MJ; Endocrinology and Nutrition, Jaen University Hospital, Av. Ejército Español, sn, Jaén, Spain.; Department of Health Sciences, University of Jaen, Campus 'Las Lagunillas', Building B3, Jaén, Spain., Soriano Arroyo R; Endocrinology and Nutrition, Jaen University Hospital, Av. Ejército Español, sn, Jaén, Spain.; Emergency Department, La Paz University Hospital, Madrid, Spain., Prieto Gomez I; Area of Physiology, University of Jaen, Campus 'Las Lagunillas', Building B3, Jaén, Spain., Segarra Robles AB; Area of Physiology, University of Jaen, Campus 'Las Lagunillas', Building B3, Jaén, Spain., Garrido-Martínez M; University of Granada, School of Dentistry, Campus 'La Cartuja', Granada, Spain., Santiago-Fernández P; Endocrinology and Nutrition, Jaen University Hospital, Av. Ejército Español, sn, Jaén, Spain., Delgado Rodríguez M; Department of Preventive Medicine and Public Health, University of Jaen, Campus 'Las Lagunillas', Building B3, Jaén, Spain.; CIBERESP, Carlos III Health Institute, Madrid, Spain. |
| Abstrakt: |
Osteoporosis results from an imbalance in bone remodeling, which is known to follow a circadian rhythm determined by a functional relationship between intestine and bone tissue. Specific intestinal peptides have been identified as mediators. Glucagon-like peptide 1 and glucagon-like peptide 2, have been associated with bone health. Our main objective was to determine whether postprandial plasma levels of glucagon-like peptide 1, glucagon-like peptide 2 and dipeptidyl-peptidase 4 activity, are associated with osteoporosis in non-diabetic postmenopausal women. We studied non-diabetic postmenopausal women with osteoporosis diagnosed by dual-energy X-ray absorptiometry (cases, n = 43) and age-matched (±1 yr) controls without osteoporosis or a history of osteoporotic fracture (n = 43). We measured postprandial plasma levels of glucagon-like peptide 1, glucagon-like peptide 2, and dipeptidyl-peptidase 4 activity, bone mineral density, and baseline levels of bone remodeling markers and analyzed the food intake using a food-frequency questionnaire. Postprandial glucagon-like peptide 1 values were lower (p < 0.001) in cases, μ (SEM) = 116.25 (2.68), than in controls, μ (SEM) = 126.79 (2.68). Glucagon-like peptide 1 was associated with reduced osteoporosis risk in the crude logistic regression analysis [OR (95% CI) = 0.724 (0.53-0.97), p = 0.031] and adjusted analysis [OR = 0.603 (0.38-0.94), p = 0.027]. We found no association of glucagon-like peptide 2, or dipeptidyl-peptidase 4 activity with osteoporosis. Postprandial glucagon-like peptide 1 levels are related to osteoporosis and osteoporosis risk in non-diabetic postmenopausal women. Further studies are required to verify these findings. |
