The postnatal presence of human chorionic gonadotropin in preterm infants and its potential inverse association with retinopathy of prematurity.

Autor: Movsas TZ; Zietchick Research Institute, Plymouth, MI, USA. tmovsas@zietchick.com.; Department of Pediatrics & Human Development, College of Human Medicine, Michigan State University, East Lansing, MI, USA. tmovsas@zietchick.com., Paneth N; Department of Pediatrics & Human Development, College of Human Medicine, Michigan State University, East Lansing, MI, USA.; Department of Epidemiology & Biostatistics, College of Human Medicine, Michigan State University, East Lansing, MI, USA., Gewolb IH; Department of Pediatrics & Human Development, College of Human Medicine, Michigan State University, East Lansing, MI, USA., Lu Q; Department of Epidemiology & Biostatistics, College of Human Medicine, Michigan State University, East Lansing, MI, USA., Cavey G; Biomedical Sciences, Western Michigan University-Homer Stryker M.D. School of Medicine, Kalamazoo, MI, USA., Muthusamy A; Zietchick Research Institute, Plymouth, MI, USA.
Jazyk: angličtina
Zdroj: Pediatric research [Pediatr Res] 2020 Feb; Vol. 87 (3), pp. 558-563. Date of Electronic Publication: 2019 Sep 19.
DOI: 10.1038/s41390-019-0580-8
Abstrakt: Background: Human chorionic gonadotropin (hCG) and luteinizing hormone (LH) are pro-angiogenic gonadotropic hormones, which classically target the reproductive organs. However, hCG, LH, and their shared CG/LH receptor are also present in the human eye. The possibility that a deficiency of these hormones may be involved in the pathogenesis of retinopathy of prematurity (ROP) during its early non-proliferative phase has not been explored.
Methods: We conducted a cross-sectional study of Michigan-born preterm infants utilizing dried blood spots. We analyzed hCG and LH blood levels at 1 week and 4 weeks of age from 113 study participants (60 without ROP; 53 with non-proliferative ROP). We utilized electrochemiluminescence assays on the Mesoscale Discovery platform.
Results: Similar levels of hCG are found in preterm infants at both 1 week and 4 weeks after birth. Preterm infants with non-proliferative ROP, after adjusting for sex and gestational age, have 2.42 [95% CI: 1.08-5.40] times the odds of having low hCG at fourth week of age.
Conclusions: We found that hCG is present postnatally in preterm infants and that a deficiency of hCG at 4 weeks of age is potentially associated with non-proliferative ROP. This provides novel evidence to suggest that hCG may participate in human retinal angiogenesis.
Databáze: MEDLINE
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