[ArticlThe application of glucocorticoid hormones for correction of spermatogenesis шт males with endocrine-dependent forms of infertility. eTitle].

Autor:	Zagarskikh EY; The research center of problems of family health and human reproduction, 664003, Irkutsk, Russia.; The medical center 'Admiralty Shipyards', 190121, St. Petersburg, Russia., Kolesnikova LI; The research center of problems of family health and human reproduction, 664003, Irkutsk, Russia., Kurashova NA; The research center of problems of family health and human reproduction, 664003, Irkutsk, Russia., Dolgikh MI; The research center of problems of family health and human reproduction, 664003, Irkutsk, Russia.
Jazyk:	ruština
Zdroj:	Klinicheskaia laboratornaia diagnostika [Klin Lab Diagn] 2016; Vol. 61 (12), pp. 810-812.
DOI:	10.18821/0869-2084-2016-61-12-810-812
Abstrakt:	Among main tasks of andrology, besides search of new pharmaceuticals, an important place takes the profound analysis of pathogenesis of formation of infertility in males in every particular case with purpose of selection of pathogenetically justified therapy. The article presents the results of application of glucocorticoid medications for normalization of indices of spermogram in males with reproduction disorders. Two age groups were examined. The first group consisted of 45 individuals of 21-35 years and the second group included 30 individuals of 36-45 years. All males were applied standard clinical laboratory analysis examination including andrologist's examination, ltrasound examination of organs of scrotum and prostate, macro- and microscopic analysis of ejaculate, hormonal analysis. The treatment of patients consisted of application of medication of glucocorticoid hormones - Dexamethasonum with dosage depending on expression of hormonal alterations (0.25 mg - 1.5 mg per day). In males with supra-renal hyper-androgeny application of glucocorticoid hormones demonstrated higher efficiency of hormone therapy for correction of the given condition at absence of any side-effects that permitted to ameliorate reproductive function by normalizing indices of spermatogenesis and level of supra-renal hormones. At the given mode of treatment of pathozoospermia in males with supra-renal hyper-androgeny occurs increasing of concentration of active spermatozoa participating in fertilization and also terms of vitality of spermatozoa and activity of spermatogenesis. It is established that similar treatment shows no side-effects on organism and it has no significant contraindications for application. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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