One-Pot Conversion of Allylic Alcohols to α-Methyl Ketones via Iron-Catalyzed Isomerization-Methylation.
| Autor: | Latham DE; Cardiff Catalysis Institute, School of Chemistry , Cardiff University , Main Building, Park Place, Cardiff , CF10 3AT , U.K., Polidano K; Cardiff Catalysis Institute, School of Chemistry , Cardiff University , Main Building, Park Place, Cardiff , CF10 3AT , U.K., Williams JMJ; Department of Chemistry , University of Bath , Claverton Down, Bath , BA2 7AY , U.K., Morrill LC; Cardiff Catalysis Institute, School of Chemistry , Cardiff University , Main Building, Park Place, Cardiff , CF10 3AT , U.K. |
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| Jazyk: | angličtina |
| Zdroj: | Organic letters [Org Lett] 2019 Oct 04; Vol. 21 (19), pp. 7914-7918. Date of Electronic Publication: 2019 Sep 19. |
| DOI: | 10.1021/acs.orglett.9b02900 |
| Abstrakt: | A one-pot iron-catalyzed conversion of allylic alcohols to α-methyl ketones has been developed. This isomerization-methylation strategy utilized a (cyclopentadienone)iron(0) carbonyl complex as precatalyst and methanol as the C1 source. A diverse range of allylic alcohols undergoes isomerization-methylation to form α-methyl ketones in good isolated yields (up to 84% isolated yield). |
| Databáze: | MEDLINE |
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