Occupational exposure to pesticides and multiple myeloma in the AGRICAN cohort.

Autor: Tual S; Institut National de la santé Et de la Recherche médicale (INSERM), Unité Mixte de Recherche (UMR) 1086 ANTICIPE, Caen, France. tual-s@baclesse.unicancer.fr.; Centre de Lutte Contre le Cancer François Baclesse, Caen, France. tual-s@baclesse.unicancer.fr., Busson A; Institut National de la santé Et de la Recherche médicale (INSERM), Unité Mixte de Recherche (UMR) 1086 ANTICIPE, Caen, France.; Université de Caen Normandie, Caen, France., Boulanger M; Institut National de la santé Et de la Recherche médicale (INSERM), Unité Mixte de Recherche (UMR) 1086 ANTICIPE, Caen, France.; Centre de Lutte Contre le Cancer François Baclesse, Caen, France., Renier M; Institut National de la santé Et de la Recherche médicale (INSERM), Unité Mixte de Recherche (UMR) 1086 ANTICIPE, Caen, France.; Université de Caen Normandie, Caen, France., Piel C; EPICENE Team, ISPED, U1219 INSERM, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France., Pouchieu C; EPICENE Team, ISPED, U1219 INSERM, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France., Pons R; Institut National de la santé Et de la Recherche médicale (INSERM), Unité Mixte de Recherche (UMR) 1086 ANTICIPE, Caen, France.; Université de Caen Normandie, Caen, France., Perrier S; Institut National de la santé Et de la Recherche médicale (INSERM), Unité Mixte de Recherche (UMR) 1086 ANTICIPE, Caen, France.; Centre de Lutte Contre le Cancer François Baclesse, Caen, France., Levêque-Morlais N; Institut National de la santé Et de la Recherche médicale (INSERM), Unité Mixte de Recherche (UMR) 1086 ANTICIPE, Caen, France.; Centre de Lutte Contre le Cancer François Baclesse, Caen, France., Karuranga P; Institut National de la santé Et de la Recherche médicale (INSERM), Unité Mixte de Recherche (UMR) 1086 ANTICIPE, Caen, France., Lemarchand C; Institut National de la santé Et de la Recherche médicale (INSERM), Unité Mixte de Recherche (UMR) 1086 ANTICIPE, Caen, France., Marcotullio E; Caisse Centrale de la Mutualité Sociale Agricole, Echelon National Santé Sécurité au Travail, Bagnolet, France., Guizard AV; Institut National de la santé Et de la Recherche médicale (INSERM), Unité Mixte de Recherche (UMR) 1086 ANTICIPE, Caen, France.; Centre de Lutte Contre le Cancer François Baclesse, Caen, France.; Registre général Des Tumeurs du Calvados, Caen, France., Monnereau A; EPICENE Team, ISPED, U1219 INSERM, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.; Hematological Malignancies Registry of Gironde, Bergonie Institute, Comprehensive Cancer Centre, Bordeaux, France., Baldi I; EPICENE Team, ISPED, U1219 INSERM, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.; CHU de Bordeaux, Service de Médecine du Travail Et Pathologies Professionnelles, Bordeaux, France., Lebailly P; Institut National de la santé Et de la Recherche médicale (INSERM), Unité Mixte de Recherche (UMR) 1086 ANTICIPE, Caen, France.; Université de Caen Normandie, Caen, France.; Centre de Lutte Contre le Cancer François Baclesse, Caen, France.
Jazyk: angličtina
Zdroj: Cancer causes & control : CCC [Cancer Causes Control] 2019 Nov; Vol. 30 (11), pp. 1243-1250. Date of Electronic Publication: 2019 Sep 18.
DOI: 10.1007/s10552-019-01230-x
Abstrakt: Purpose: Epidemiological studies have found an increased risk of multiple myeloma (MM) in farmers. Few studies have investigated the detailed circumstances of occupational pesticide exposure which could explain these increased risks (pesticide use on crops, seeds or on animals, contact with treated crops) and the role of other exposures. In the Agriculture and Cancer cohort (AGRICAN), we assessed the associations between MM and crop- or animal-related activities, with specific attention to pesticide exposure via use on animals and crops or contact with treated crops and to disinfectant exposure.
Methods: Analyses concerned 155,192 participants, including 269 incident MM identified by cancer registries from enrolment (2005-2007) to 2013. Cox models using attained age as time scale were run to calculate hazard ratios (HR) and 95% confidence intervals (CI).
Results: MM risk was increased in farmers (i) who started using pesticides on crops in the 1960s, especially among those applying pesticides on corn (≥ 20 years: HR 1.73, 95% CI 1.08, 2.78, p for trend < 0.01) and (ii) using insecticides on animals (HR 1.48, 95% CI 1.11, 1.98), especially among horse farmers (≥ 10 years: HR 2.77, 95% CI 1.22-6.27, p for trend = 0.01). We also observed significant elevated risks with disinfectant use in animal barns.
Conclusions: Findings support the role of pesticide use on crops and animals in the occurrence of MM risk in farmers.
Databáze: MEDLINE
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