Surface tension determines tissue shape and growth kinetics.

Autor: Ehrig S; Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany., Schamberger B; Paris-Lodron University of Salzburg, Department of the Chemistry and Physics of Materials, Salzburg, Austria., Bidan CM; Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany.; Université Grenoble Alpes, CNRS, Laboratoire Interdisciplinaire de Physique (LIPhy), Grenoble, France., West A; Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany., Jacobi C; Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany., Lam K; Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany., Kollmannsberger P; Center for Computational and Theoretical Biology, University of Würzburg, Germany., Petersen A; Berlin-Brandenburg Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Berlin, Germany., Tomancak P; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany., Kommareddy K; Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany., Fischer FD; Montanuniversität Leoben, Institute of Mechanics, Leoben, Austria., Fratzl P; Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany., Dunlop JWC; Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany.; Paris-Lodron University of Salzburg, Department of the Chemistry and Physics of Materials, Salzburg, Austria.
Jazyk: angličtina
Zdroj: Science advances [Sci Adv] 2019 Sep 11; Vol. 5 (9), pp. eaav9394. Date of Electronic Publication: 2019 Sep 11 (Print Publication: 2019).
DOI: 10.1126/sciadv.aav9394
Abstrakt: The collective self-organization of cells into three-dimensional structures can give rise to emergent physical properties such as fluid behavior. Here, we demonstrate that tissues growing on curved surfaces develop shapes with outer boundaries of constant mean curvature, similar to the energy minimizing forms of liquids wetting a surface. The amount of tissue formed depends on the shape of the substrate, with more tissue being deposited on highly concave surfaces, indicating a mechano-biological feedback mechanism. Inhibiting cell-contractility further revealed that active cellular forces are essential for generating sufficient surface stresses for the liquid-like behavior and growth of the tissue. This suggests that the mechanical signaling between cells and their physical environment, along with the continuous reorganization of cells and matrix is a key principle for the emergence of tissue shape.
Databáze: MEDLINE