Clinical and laboratory parameters and morphological characteristics of the endometrium in women with impaired fat metabolism and failed IVF attempts.

Autor: Lisovskaya TV; FSBI 'Ural Research Institute for Maternity and Childcare' of the Ministry of Health of Russia , Ekaterinburg , Russia.; Clinical Institute for Reproductive Medicine , Ekaterinburg , Russia., Perepletina TA; FSBI 'Ural Research Institute for Maternity and Childcare' of the Ministry of Health of Russia , Ekaterinburg , Russia., Sevost' Yanova OY; FGBI of Higher Education 'Ural State Medical University' of the Ministry of Health of Russia , Ekaterinburg , Russia., Mayasina EN; Clinical Institute for Reproductive Medicine , Ekaterinburg , Russia., Salimov DF; Clinical Institute for Reproductive Medicine , Ekaterinburg , Russia., Osipenko AA; Clinical Institute for Reproductive Medicine , Ekaterinburg , Russia.
Jazyk: angličtina
Zdroj: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology [Gynecol Endocrinol] 2019; Vol. 35 (sup1), pp. 41-44.
DOI: 10.1080/09513590.2019.1653561
Abstrakt: Objective: To study clinical and laboratory parameters and morphological characteristics of the endometrium in women with impaired fat metabolism and failed IVF attempts. Materials and methods: Clinical examination, laboratory tests, morphological analysis, and immunohistochemistry of the endometrium were conducted in 76 patients with different BMI, followed up with infertility and failed IVF attempts. Patients were divided into four groups by body mass index (BMI): 1 group - 17 women with overweight, BMI = 25.0 - 29.9 kg/m 2 ; 2 group - 15 women with class I obesity, BMI 30.0-34.9 kg/m 2 ; 3 group - 14 women with class II obesity, BMI 35.0-39.9 kg/m 2 ; and the control group of 30 women with normal weight, BMI 18.5-24.9 kg/m 2 . Results: Clinical and laboratory analysis revealed menstrual irregularities and hormonal imbalance such as hypoestrogenism. Immunohistochemistry of the endometrium found a significant decrease in the expression of ERα and PR receptors in the glands correlated to increasing BMI. Conclusion: Pregravid preparation of women with increased BMI and failed IVF attempts has to include life-style modification and weight reduction program to restore normal hormonal status and expression of estrogen and progesterone receptors, prevention of excessive proliferative processes in the endometrium, and improving endometrial receptivity.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje