Primary malignant melanoma of the biliary tract: A case report and literature review.

Autor:	Cameselle-García S; Department of Medical Oncology, Complejo Hospitalario Universitario de Ourense, SERGAS, Ourense 32005, Spain. soledad.cameselle.garcia@sergas.es., Pérez JLF; Department of Medical Oncology, Complejo Hospitalario Universitario de Ourense, SERGAS, Ourense 32005, Spain., Areses MC; Department of Medical Oncology, Complejo Hospitalario Universitario de Ourense, SERGAS, Ourense 32005, Spain., de Castro JDF; Department of Digestive, Complejo Hospitalario Universitario de Ourense, SERGAS, Ourense 32005, Spain., Mosquera-Reboredo J; Department of Pathology, Hospital San Rafael, A Coruña 15009, Spain., García-Mata J; Department of Medical Oncology, Complejo Hospitalario Universitario de Ourense, SERGAS, Ourense 32005, Spain.
Jazyk:	angličtina
Zdroj:	World journal of clinical cases [World J Clin Cases] 2019 Aug 26; Vol. 7 (16), pp. 2302-2308.
DOI:	10.12998/wjcc.v7.i16.2302
Abstrakt:	Background: Primary malignant melanoma of the biliary tract (MBT) is a rare condition whose diagnosis requires excluding a primary origin in another location. This paper reviews the most important characteristics of MBT cases published in the literature and reports a new case. The patient reported here is the first case of primary malignant melanoma of the biliary tract with pulmonary metastasis treated with immunotherapy. This patient remains disease-free 36 mo after the treatment of metastatic lung lesions. Case Summary: A 51-year-old man was admitted to the gastrointestinal department to study obstructive jaundice of a 1 wk clinical course. Magnetic resonance cholangiopancreatography revealed dilatation of the intrahepatic biliary tract and stenosis of the common hepatic duct. Given the suspicion of biliary tract neoplasia, cholecystectomy and resection of the common hepatic duct were performed with hepatic jejunostomy free of complications. Anatomo-pathological diagnosis was melanoma. After intervention, the patient was referred to the Department of Medical Oncology, where a primary origin was excluded in the skin, mucosa, and eyes. This confirmed diagnosis of primary biliary tract melanoma. Computed tomography was performed 12 mo after the procedure revealed several subcentimetric lung nodules. Wedge resection was performed. After confirming the diagnosis of pulmonary metastasis of primary melanoma of the biliary tract, the patient was started on immunotherapy with nivolumab. Tolerance to treatment was excellent. The patient remains disease-free 36 mo after the treatment of metastatic lung lesions. Conclusion: The patient reported here is the first case of primary malignant melanoma of the biliary tract with lung metastases successfully treated with immunotherapy. Competing Interests: Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Databáze:	MEDLINE
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