Prevalence of silicone oil droplets in eyes treated with intravitreal injection.

Autor: Melo GB; Hospital de Olhos de Sergipe, Rua Campo do Brito, 995 São José, Aracaju, SE 49020-380 Brazil.; 2Federal University of São Paulo, São Paulo, SP Brazil., Dias Junior CS; Hospital de Olhos de Sergipe, Rua Campo do Brito, 995 São José, Aracaju, SE 49020-380 Brazil., Morais FB; Hospital de Olhos de Sergipe, Rua Campo do Brito, 995 São José, Aracaju, SE 49020-380 Brazil.; 2Federal University of São Paulo, São Paulo, SP Brazil., Cardoso AL; Hospital de Olhos de Sergipe, Rua Campo do Brito, 995 São José, Aracaju, SE 49020-380 Brazil., Figueiredo AGA; 3Tiradentes University-UNIT, Aracaju, SE Brazil., Lima Filho AAS; 2Federal University of São Paulo, São Paulo, SP Brazil., Rodrigues EB; 2Federal University of São Paulo, São Paulo, SP Brazil., Emerson GG; Retina Center of Minnesota, Minneapolis, MN USA., Maia M; 2Federal University of São Paulo, São Paulo, SP Brazil.
Jazyk: angličtina
Zdroj: International journal of retina and vitreous [Int J Retina Vitreous] 2019 Sep 11; Vol. 5, pp. 34. Date of Electronic Publication: 2019 Sep 11 (Print Publication: 2019).
DOI: 10.1186/s40942-019-0184-9
Abstrakt: Objective: To assess the number of eyes with silicone oil in the vitreous after intravitreal injection.
Methods: This cross-sectional, comparative study was divided into 2 groups: (1) treatment-eyes subjected to antiangiogenic therapy; (2) control-no history of intravitreal injection. Subjects were assessed regarding age, gender, clinical diagnosis, lens status, visual acuity and number of previous intravitreal injections. All eyes underwent a meticulous slit-lamp and ultrasound examination for the identification of silicone oil. ImageJ software was used to quantify the index of silicone oil (IOS) by ultrasonography.
Results: Sixty-seven eyes (30 controls, 37 treated) were included. Slit-lamp examination found silicone oil droplets in 25 out of 37 (67.57%) treated eyes and in none of the control group. Ultrasonography identified silicone oil in 28 out of 37 (75.68%) treated eyes and in 1 out of 30 (3.33%) controls. An observed agreement of 85.07% and a Cohen's Kappa coefficient of 69.10% (p < 0.0001) between ultrasonography and biomicroscopy were found. Wilcoxon test showed a statistically significant difference (p = 0.0006) in IOS between controls (0.41 ± 0.43%) and treated eyes (2.69 ± 2.55%). Spearman's correlation test (0.61; p < 0.0001) showed that the greater the number of injections, the higher the IOS.
Conclusions: Silicone oil droplets were found in the majority of the eyes previously treated with antiangiogenic intravitreal injection. The greater the number of injections, the higher the likelihood of finding silicone oil. An improvement in the technique of injection and better-quality syringes post-injection silicone oil droplets.
Competing Interests: Competing interestsThe authors declare that they have no competing interests.
Databáze: MEDLINE
Externí odkaz: