Τhe Co-Existence of Obstructive Sleep Apnea and Bronchial Asthma: Revelation of a New Asthma Phenotype?

Autor: Damianaki A; Pulmonary Department 'Saint George' General Hospital of Chania, 73300 Crete, Greece.; First ICU Clinic, National and Kapodistrian University of Athens, 10561 Athens, Greece., Vagiakis E; Sleep Lab, First ICU Clinic Evangelismos Hospital, 10676 Athens, Greece., Sigala I; Sleep Lab, First ICU Clinic Evangelismos Hospital, 10676 Athens, Greece., Pataka A; Respiratory Failure Unit, G. Papanikolaou Hospital, Exohi, Aristotle University of Thessaloniki, 57010 Thessaloniki, Greece., Rovina N; ICU, First Department of Pulmonary Medicine, Sotiria Hospital, 115 27 Athens, Greece., Vlachou A; First ICU Clinic, National and Kapodistrian University of Athens, 10561 Athens, Greece., Krietsepi V; Pulmonary Department 'Saint George' General Hospital of Chania, 73300 Crete, Greece., Zakynthinos S; First ICU Clinic, National and Kapodistrian University of Athens, 10561 Athens, Greece.; Sleep Lab, First ICU Clinic Evangelismos Hospital, 10676 Athens, Greece., Katsaounou P; First ICU Clinic, National and Kapodistrian University of Athens, 10561 Athens, Greece. paraskevikatsaounou@gmail.com.; Sleep Lab, First ICU Clinic Evangelismos Hospital, 10676 Athens, Greece. paraskevikatsaounou@gmail.com.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2019 Sep 16; Vol. 8 (9). Date of Electronic Publication: 2019 Sep 16.
DOI: 10.3390/jcm8091476
Abstrakt: Bronchial asthma (BA) and obstructive sleep apnea (OSA) are common respiratory obstructive diseases that may coexist. It would be interesting to study the possible influence of that coexistence on both diseases. Until now, reviews focused mainly on epidemiology. The aim of this study was to review the literature in relation to epidemiology, pathophysiology, consequences, screening of patients, and treatment of the coexistence of OSA and BA. We pooled studies from the PubMed database from 1986 to 2019. OSA prevalence in asthmatics was found to be high, ranging from19% to 60% in non-severe BA, reaching up to 95% in severe asthma. Prevalence was correlated with the duration and severity of BA, and increased dosage of steroids taken orally or by inhalation. This high prevalence of the coexistence of OSA and BA diseases could not be a result of just chance. It seems that this coexistence is based on the pathophysiology of the diseases. In most studies, OSA seems to deteriorate asthma outcomes, and mainly exacerbates them. CPAP (continuous positive airway pressure) treatment is likely to improve symptoms, the control of the disease, and the quality of life in asthmatics with OSA. However, almost all studies are observational, involving a small number of patients with a short period of follow up. Although treatment guidelines cannot be released, we could recommend periodic screening of asthmatics for OSA for the optimal treatment of both the diseases.
Competing Interests: The authors declare no conflict of interest.
Databáze: MEDLINE
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