Association of Fetuin-B with Subclinical Atherosclerosis in Obese Chinese Adults.

Autor:	Li Z; Epidemiology Research Unit, The First Affiliated Hospital of Xiamen University., He C; Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University., Liu Y; Department of Nursing, The First Affiliated Hospital of Xiamen University., Wang D; School of Medicine, Xiamen University of Xiamen., Lin M; Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University., Liu C; Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University.; Department of Endocrinology and Diabetes, the Teaching Hospital of Fujian Medical University., Shi X; Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University., Chen Z; Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University., Li X; Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University., Yang S; Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University., Li W; Department of Cardiology, The First Affiliated Hospital of Xiamen University.
Jazyk:	angličtina
Zdroj:	Journal of atherosclerosis and thrombosis [J Atheroscler Thromb] 2020 May 01; Vol. 27 (5), pp. 418-428. Date of Electronic Publication: 2019 Sep 13.
DOI:	10.5551/jat.49619
Abstrakt:	Aim: We aimed to explore the independent associations of serum Fetuin-B and common genetic variants in FETUB locus with subclinical atherosclerosis. Methods: A cross-sectional study of 1,140 obese adults, who underwent serum Fetuin-B testing, hepatic ultrasonography scanning, genotyping on four tagging single nucleotide polymorphisms (SNPs) in FETUB locus and atherosclerosis detection, was conducted in Xiamen, China. Results: Increasing tertiles of brachial ankle pulse wave velocity (ba-PWV) were significantly associated with higher prevalence of nonalcoholic fatty liver disease (NAFLD) (48.8%, 61.5%, and 70.5% for tertiles of 1-3, respectively, p＜0.001) and serum Fetuin-B (3.85±1.39, 4.09±1.40, and 4.27±1.46 µg/ml, p=0.047). Multivariable linear regression analyses with adjustment for potential confounding factors, even NAFLD per se, showed that serum Fetuin-B were significantly and positively associated with ba-PWV, with standardized regression coefficients (β) ranging from 0.055 to 0.075 (all p-values ＜0.05) in different models. However, the significant relationship between serum Fetuin-B and ba-PWV disappeared with further adjustment for insulin resistance. Serum Fetuin-B was not significantly associated with ankle-brachial index (ABI). All genotypes of the four tested FETUB tagging SNPs were not significantly associated with either ba-PWV or ABI with adjustment for potential confounding factors. Conclusion: Serum Fetuin-B was positively associated with ba-PWV and may link liver fat accumulation to subclinical atherosclerosis via insulin resistance.
Databáze:	MEDLINE
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