Fluoxetine exposure disrupts food intake and energy storage in the cichlid fish Cichlasoma dimerus (Teleostei, Cichliformes).

Autor: Dorelle LS; CONICET-Universidad de Buenos Aires, Instituto de Biodiversidad y Biología Experimental Aplicada (IBBEA), Laboratorio de Ecotoxicología Acuática, Buenos Aires, Argentina., Da Cuña RH; CONICET-Universidad de Buenos Aires, Instituto de Biodiversidad y Biología Experimental Aplicada (IBBEA), Laboratorio de Ecotoxicología Acuática, Buenos Aires, Argentina; Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Biodiversidad y Biología Experimental, Argentina., Sganga DE; CONICET-Universidad de Buenos Aires, Instituto de Biodiversidad y Biología Experimental Aplicada (IBBEA), Laboratorio de Biología de la Reproducción, Crecimiento y Nutrición de Crustáceos Decápodos, Buenos Aires, Argentina., Rey Vázquez G; CONICET-Universidad de Buenos Aires, Instituto de Biodiversidad y Biología Experimental Aplicada (IBBEA), Laboratorio de Ecotoxicología Acuática, Buenos Aires, Argentina; Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Biodiversidad y Biología Experimental, Argentina., López Greco L; Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Biodiversidad y Biología Experimental, Argentina; CONICET-Universidad de Buenos Aires, Instituto de Biodiversidad y Biología Experimental Aplicada (IBBEA), Laboratorio de Biología de la Reproducción, Crecimiento y Nutrición de Crustáceos Decápodos, Buenos Aires, Argentina., Lo Nostro FL; CONICET-Universidad de Buenos Aires, Instituto de Biodiversidad y Biología Experimental Aplicada (IBBEA), Laboratorio de Ecotoxicología Acuática, Buenos Aires, Argentina; Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Biodiversidad y Biología Experimental, Argentina. Electronic address: f.lonostro@gmail.com.
Jazyk: angličtina
Zdroj: Chemosphere [Chemosphere] 2020 Jan; Vol. 238, pp. 124609. Date of Electronic Publication: 2019 Aug 17.
DOI: 10.1016/j.chemosphere.2019.124609
Abstrakt: Human pharmaceuticals are pollutants of special concern due to their widespread consumption over the last decades, their high persistence in the environment, and the reported alterations produced on non-target organism. The antidepressant fluoxetine (FLX) exerts its effect by inhibiting serotonin (5-HT) reuptake at the presynaptic membrane, thus increasing brain serotonergic activity. In vertebrates, there is a clear inverse relationship between hypothalamic 5-HT levels and food intake, therefore we hypothesized that FLX would inhibit food intake, and in consequence alter energy metabolism in freshwater fish. The aim of this study was to analyze the effect of FLX on feeding behavior and energy storage of the cichlid fish Cichlasoma dimerus. Adult fish were intraperitoneally injected daily with 2 or 20 μg.g -1 FLX or saline for a 5-day period, during which the 20 μg.g - 1 FLX-injected fish exhibited a marked reduction in food intake, consistent with a decrease in total body weight and total hepatocyte area observed at the end of the experiment. Although not statistically significant, a marked 50% decrease in glycogen and lipid content and an increase in protein levels in liver was observed for the 20 μg.g - 1 FLX dose. This was evidenced histochemically by a weak PAS positive reaction and an intense Coomasie Blue stain. Taken together, these results suggest that the SSRI antidepressant FLX produces an anorectic effect in adults of C. dimerus, which could alter normal physiological function and, in consequence, have a negative impact on fish growth, reproduction, and population success.
(Copyright © 2019 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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