The Glypican-4 Gene Polymorphism rs1048369 and Susceptibility to Epstein-Barr Virus-Positive and -Negative Nasopharyngeal Carcinoma in Northern China.

Autor: Liu S; Department of Transfusion Medicine, The Affiliated Hospital of Qingdao University, Qingdao, China.; Department of Medical Microbiology, Qingdao University Medical College, Qingdao, China., Liu W; Department of Medical Microbiology, Qingdao University Medical College, Qingdao, China., Zhao D; Department of Medical Microbiology, Qingdao University Medical College, Qingdao, China., Zhang Y; Department of Medical Microbiology, Qingdao University Medical College, Qingdao, China.; Department of Clinical Laboratory, Zibo Central Hospital, Zibo, China., Zhao Z; Department of Medical Microbiology, Qingdao University Medical College, Qingdao, China., Luo B; Department of Medical Microbiology, Qingdao University Medical College, Qingdao, China, qdluobing@163.com.
Jazyk: angličtina
Zdroj: Oncology research and treatment [Oncol Res Treat] 2019; Vol. 42 (11), pp. 572-579. Date of Electronic Publication: 2019 Sep 13.
DOI: 10.1159/000502753
Abstrakt: Background: Gene polymorphism rs1048369 of glypican-4 (GPC4) gene has been reported to be significantly different between Epstein-Barr virus (EBV)-associated gastric carcinoma (GC) and EBV-negative GC. However, little is known about the polymorphism in nasopharyngeal carcinoma (NPC), which is a malignant tumor with a high prevalence of EBV.
Objective: The distribution of GPC4 polymorphism rs1048369 was investigated in NPC patients, especially in those with EBV infection. The association between the polymorphism of GPC4 and the susceptibility to EBV-positive and EBV-negative NPC was also explored.
Patients and Methods: The GPC4 gene polymorphism rs1048369 was detected in 143 cases of EBV-positive NPC and in 19 cases of EBV-negative NPC using polymerase chain reaction. One hundred and seven peripheral blood samples from healthy individuals were also measured as a control group.
Results: The difference in genotype CC between EBV-positive NPC patients and healthy individuals was significant (χ2 = 15.273, p < 0.01). No significant difference was observed between EBV-positive and EBV-negative NPC cases. Between EBV-negative NPC cases and healthy individuals, there was no significant difference in GPC4 gene polymorphism in both genotypic and allelic frequencies.
Conclusions: The GPC4 gene polymorphism is associated with susceptibility to EBV-positive NPC. The CC genotype of GPC4 may represent a risk factor for NPC in Northern China.
(© 2019 S. Karger AG, Basel.)
Databáze: MEDLINE
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