Are early increases in physical activity a behavioral marker for successful antidepressant treatment?

Autor: Yun L; School of Kinesiology, University of British Columbia, Room 337, Lower Mall Research Station, 2259 Lower Mall, Vancouver, BC Canada V6T 1Z4. Electronic address: lira.yun@ubc.ca., Fagan M; School of Kinesiology, University of British Columbia, Room 337, Lower Mall Research Station, 2259 Lower Mall, Vancouver, BC Canada V6T 1Z4. Electronic address: matthew.fagan@ubc.ca., Subramaniapillai M; Mood Disorders Psychopharmacology Unit (MDPU), University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address: m.subram@mail.utoronto.ca., Lee Y; Mood Disorders Psychopharmacology Unit (MDPU), University Health Network, University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. Electronic address: yenalee.lee@mail.utoronto.ca., Park C; Mood Disorders Psychopharmacology Unit (MDPU), University Health Network, University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. Electronic address: caroline.park@mail.utoronto.ca., Mansur RB; Mood Disorders Psychopharmacology Unit (MDPU), University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address: rodrigo.mansur@uhn.ca., McIntyre RS; Mood Disorders Psychopharmacology Unit (MDPU), Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada; Brain and Cognition Discovery Foundation (BCDF), Toronto, Ontario, Canada. Electronic address: roger.mcintyre@uhn.ca., Faulkner GEJ; School of Kinesiology, University of British Columbia, Room 337, Lower Mall Research Station, 2259 Lower Mall, Vancouver, BC Canada V6T 1Z4. Electronic address: guy.faulkner@ubc.ca.
Jazyk: angličtina
Zdroj: Journal of affective disorders [J Affect Disord] 2020 Jan 01; Vol. 260, pp. 287-291. Date of Electronic Publication: 2019 Sep 03.
DOI: 10.1016/j.jad.2019.09.002
Abstrakt: Background: The aim of this study was to examine whether changes in physical activity predicted reductions in depression during the 8 weeks of antidepressant treatment with vortioxetine.
Methods: One hundred individuals were recruited for the (THINC-it ®)-sensitivity to change study. Self-reported moderate-to-vigorous physical activity (MVPA) and depression severity were assessed at baseline, week 4 and week 8. Linear mixed model analyses were performed to examine whether increases in MVPA were associated with reduction in depression severity over the course of treatment and hierarchical logistic regression analyses were performed to assess whether treatment response (responders vs. non-responders) at week 8 was predicted by early change in physical activity (MVPA at week 4), after controlling for individuals' demographics (sex, age, race, education level, BMI) and baseline MVPA and depression severity.
Results: After controlling for individuals' demographics, a significant increase in MVPA predicted reduction in depression severity, β = -2.06, 95% CI -3.18, -0.94, p <0.001. Individuals with more physical activity at week 4 relative to baseline had higher odds of treatment response at endpoint, OR 1.97, 95% CI 1.11 - 3.48, p <0.05. Twenty-one percent of total variance of depression severity was explained by change in MVPA.
Conclusions: The study suggests that early increases in physical activity may be a behavioral marker of antidepressant treatment response. The inclusion of physical activity measures in future clinical treatment trials of depression is recommended to explore whether changes in physical activity mediate or moderate reductions in depression severity associated with the primary treatment.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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