New insights into progesterone actions on prolactin secretion and prolactinoma development.

Autor: Camilletti MA; Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina., Abeledo-Machado A; Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina., Faraoni EY; Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina., Thomas P; Marine Science Institute, University of Texas at Austin, Port Aransas, TX, USA., Díaz-Torga G; Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina. Electronic address: gdiaz@ibyme.conicet.gov.ar.
Jazyk: angličtina
Zdroj: Steroids [Steroids] 2019 Dec; Vol. 152, pp. 108496. Date of Electronic Publication: 2019 Sep 12.
DOI: 10.1016/j.steroids.2019.108496
Abstrakt: Progesterone (P4) has controversial physiological effects on the regulation of the lactotroph population. While some studies have shown a negative role for P4 in prolactin secretion and lactotroph proliferation, antagonizing estradiol effects, others demonstrated a proliferative role of P4 at the pituitary level. Usually, progesterone actions in the pituitary gland were studied through their classical, genomic pathways triggered by nuclear progesterone receptors (nPRs). However, in 2003, the scene became more complex with the discovery of another group of progesterone receptors involved in rapid, non-genomic P4 effects: the membrane progesterone receptors (mPRs), which are members of the progesterone and adipoQ receptor (PAQR) family. This review examines the historical background and current data on the study of progesterone actions on PRL secretion providing new evidence of P4 effects at the hypothalamic and at the pituitary level through non-classic P4-receptors. In addition, we explore the role of progesterone in the development of experimental prolactinomas, a controversial topic in the literature.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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