Hippocampal-Prefrontal Theta Transmission Regulates Avoidance Behavior.

Autor:	Padilla-Coreano N; Systems Neuroscience Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Canetta S; Department of Psychiatry, Columbia University Medical Center, 1051 Riverside Drive, New York, NY 10032, USA; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032, USA., Mikofsky RM; Integrative Neuroscience Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA., Alway E; Integrative Neuroscience Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA., Passecker J; Integrative Neuroscience Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA; Zuckerman Mind Brain Behavior Institute, New York, NY 10027, USA., Myroshnychenko MV; Integrative Neuroscience Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA., Garcia-Garcia AL; Department of Psychiatry, Columbia University Medical Center, 1051 Riverside Drive, New York, NY 10032, USA., Warren R; Department of Psychiatry, Columbia University Medical Center, 1051 Riverside Drive, New York, NY 10032, USA., Teboul E; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032, USA., Blackman DR; Department of Psychiatry, Columbia University Medical Center, 1051 Riverside Drive, New York, NY 10032, USA., Morton MP; Department of Psychiatry, Columbia University Medical Center, 1051 Riverside Drive, New York, NY 10032, USA., Hupalo S; Integrative Neuroscience Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA., Tye KM; Systems Neuroscience Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Kellendonk C; Department of Psychiatry, Columbia University Medical Center, 1051 Riverside Drive, New York, NY 10032, USA; Department of Pharmacology, Columbia University Medical Center, 1051 Riverside Drive, New York, NY 10032, USA; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032, USA., Kupferschmidt DA; Integrative Neuroscience Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA., Gordon JA; Integrative Neuroscience Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA; National Institute of Mental Health, NIH, Bethesda, MD 20892, USA. Electronic address: joshua.gordon@nih.gov.
Jazyk:	angličtina
Zdroj:	Neuron [Neuron] 2019 Nov 06; Vol. 104 (3), pp. 601-610.e4. Date of Electronic Publication: 2019 Sep 11.
DOI:	10.1016/j.neuron.2019.08.006
Abstrakt:	Long-range synchronization of neural oscillations correlates with distinct behaviors, yet its causal role remains unproven. In mice, tests of avoidance behavior evoke increases in theta-frequency (∼8 Hz) oscillatory synchrony between the ventral hippocampus (vHPC) and medial prefrontal cortex (mPFC). To test the causal role of this synchrony, we dynamically modulated vHPC-mPFC terminal activity using optogenetic stimulation. Oscillatory stimulation at 8 Hz maximally increased avoidance behavior compared to 2, 4, and 20 Hz. Moreover, avoidance behavior was selectively increased when 8-Hz stimulation was delivered in an oscillatory, but not pulsatile, manner. Furthermore, 8-Hz oscillatory stimulation enhanced vHPC-mPFC neurotransmission and entrained neural activity in the vHPC-mPFC network, resulting in increased synchrony between vHPC theta activity and mPFC spiking. These data suggest a privileged role for vHPC-mPFC theta-frequency communication in generating avoidance behavior and provide direct evidence that synchronized oscillations play a role in facilitating neural transmission and behavior. (Published by Elsevier Inc.)
Databáze:	MEDLINE
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