Can Paraplegia by Disruption of the Spinal Cord Tissue Be Reversed? The Signs of a New Perspective.

Autor: Branco É; Institute of Animal Health and Production, Faculty of Veterinary Medicine, Federal Rural University of Amazonia, Belém, Brazil., Alves JGR; Institute of Animal Health and Production, Faculty of Veterinary Medicine, Federal Rural University of Amazonia, Belém, Brazil., Pinheiro LL; Institute of Animal Health and Production, Faculty of Veterinary Medicine, Federal Rural University of Amazonia, Belém, Brazil., Coutinho LN; Institute of Animal Health and Production, Faculty of Veterinary Medicine, Federal Rural University of Amazonia, Belém, Brazil., Gomes CRM; Institute of Animal Health and Production, Faculty of Veterinary Medicine, Federal Rural University of Amazonia, Belém, Brazil., Galvão GR; Institute of Animal Health and Production, Faculty of Veterinary Medicine, Federal Rural University of Amazonia, Belém, Brazil., de Oliveira Dos Santos GR; Freelance Veterinary Medicine, Belém, Brazil., Moreira LFM; Institute of Animal Health and Production, Faculty of Veterinary Medicine, Federal Rural University of Amazonia, Belém, Brazil., David MBM; Institute of Animal Health and Production, Faculty of Veterinary Medicine, Federal Rural University of Amazonia, Belém, Brazil., Martins DM; Institute of Animal Health and Production, Faculty of Veterinary Medicine, Federal Rural University of Amazonia, Belém, Brazil., de Oliveira EHC; Laboratory of Tissue Culture and Cytogenetics, SAMAM, Evandro Chagas Institute, Ananindeua, Brazil.; Institute of Natural Sciences, Federal University of Pará, Belém, Brazil., de Souza MPC; Laboratory of Tissue Culture and Cytogenetics, SAMAM, Evandro Chagas Institute, Ananindeua, Brazil.; Institute of Natural Sciences, Federal University of Pará, Belém, Brazil., Beltrão-Braga PCB; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Russo FB; Department of Surgery, Faculty of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil., Pignatari GC; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., de Carvalho Miranda CMF; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., de Lima AR; Institute of Animal Health and Production, Faculty of Veterinary Medicine, Federal Rural University of Amazonia, Belém, Brazil.
Jazyk: angličtina
Zdroj: Anatomical record (Hoboken, N.J. : 2007) [Anat Rec (Hoboken)] 2020 Jul; Vol. 303 (7), pp. 1812-1820. Date of Electronic Publication: 2019 Oct 29.
DOI: 10.1002/ar.24262
Abstrakt: Central nervous system (CNS) trauma is often related to tissue loss, leading to partial or complete disruption of spinal cord function due to neuronal death. Although generally irreversible, traditional therapeutic efforts, such as physical therapy exercises, are generally recommended, but with a poor or reduced improvement of the microenvironment, which in turn stimulates neuroplasticity and neuroregeneration. Mesenchymal stem cells (MSCs) have paracrine, immunomodulatory, and anti-inflammatory effects. Here we use stem cells to see if they can promote not only physical but also the functional regeneration of neuronal tissue in dogs with CNS traumas. Two dogs, one with chronic spinal cord injury and one with subacute spinal cord injury, underwent infusion of autologous MSCs in association with physiotherapy. The two treatments in combination were able to partially or completely recover the dog's walking movement again. The treatment of MSCs in association with physical therapy improved the microenvironment, which could be evidence of a paradigm shift that the CNS is not capable of functional regeneration after aggressive traumas. Anat Rec, 2019. © 2019 American Association for Anatomy Anat Rec, 303:1812-1820, 2020. © 2019 American Association for Anatomy.
(© 2019 American Association for Anatomy.)
Databáze: MEDLINE
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