Determination of Mesothelin Levels in Pleural Effusion Does Not Help Predict Survival of Patients With Malignant Pleural Mesothelioma.

Autor:	Fontana V; Clinical Epidemiology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Pistillo MP; Tumor Epigenetics Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Vigani A; Oncology Division, Azienda Sanitaria Locale n. 5 'Spezzino', La Spezia, Italy., Canessa PA; Pneumology Division, Azienda Sanitaria Locale n. 5 'Spezzino', La Spezia, Italy., Berisso G; Medicine Division, Azienda Sanitaria Locale n. 5 'Spezzino', La Spezia, Italy., Giannoni U; Radiodiagnostic Division, Azienda Sanitaria Locale n. 5 'Spezzino', La Spezia, Italy., Ferro P; Histopathology and Cytopathology Division, Azienda Sanitaria Locale n. 5 'Spezzino', La Spezia, Italy., Franceschini MC; Histopathology and Cytopathology Division, Azienda Sanitaria Locale n. 5 'Spezzino', La Spezia, Italy., Carosio R; Tumor Epigenetics Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Tonarelli M; Histopathology and Cytopathology Division, Azienda Sanitaria Locale n. 5 'Spezzino', La Spezia, Italy., Rossi C; Histopathology and Cytopathology Division, Azienda Sanitaria Locale n. 5 'Spezzino', La Spezia, Italy., Dessanti P; Histopathology and Cytopathology Division, Azienda Sanitaria Locale n. 5 'Spezzino', La Spezia, Italy., Roncella S; Histopathology and Cytopathology Division, Azienda Sanitaria Locale n. 5 'Spezzino', La Spezia, Italy silvio.roncella@gmail.com.
Jazyk:	angličtina
Zdroj:	Anticancer research [Anticancer Res] 2019 Sep; Vol. 39 (9), pp. 5219-5223.
DOI:	10.21873/anticanres.13719
Abstrakt:	Aim: This study evaluated the prognostic value of soluble mesothelin-related protein (SMRP) levels in pleural effusions (PE) from patients with pleural mesothelioma (MPM). Patients and Methods: SMRP level in PE was tested using an enzyme-linked immunosorbent assay (ELISA) in 109 patients with MPM at diagnosis before any treatment. The Kaplan-Meier method and the Cox regression were applied to compare overall survival probabilities across tertile categories of SMRP level. Results: No significant differences in Kaplan-Meier overall survival probabilities among the SMRP categories were found. A statistically non-significant trend for increased death rate ratio (RR) was computed (p=0.327) when the higher (>46.5 nM, RR=1.38) and intermediate (8.5-46.5 nM, RR=1.18) SMRP categories were compared to the lower category (<8.5 nM, RR=1.00). Cox regression modelling including a restricted cubic spline showed a moderately rising non-linear trend in death rate. Conclusion: The SMRP level in PE does not appear to have prognostic significance and its detection is not recommended in routine clinical management of patients with MPM. (Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
Databáze:	MEDLINE
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