Ergometrine stability in postpartum haemorrhage kits: Does temperature and light matter?

Autor: Donnan F; Pharmacy Department, Fiona Stanley Hospital, Perth, Western Australia, Australia., Senarathna SMDKG; School of Pharmacy and Biomedical Sciences, Curtin University, Perth, Western Australia, Australia., Ware B; Pharmacy Department, Perth Children's Hospital, Perth, Western Australia, Australia., Rawlins MDM; Pharmacy Department, Fiona Stanley Hospital, Perth, Western Australia, Australia., Dontham C; Department of Obstetrics and Gynaecology, Fiona Stanley Hospital, Perth, Western Australia, Australia., Chuang VTG; School of Pharmacy and Biomedical Sciences, Curtin University, Perth, Western Australia, Australia.; School of Pharmacy, Monash University Malaysia, Selangor, Malaysia., Batty KT; School of Pharmacy and Biomedical Sciences, Curtin University, Perth, Western Australia, Australia.
Jazyk: angličtina
Zdroj: The Australian & New Zealand journal of obstetrics & gynaecology [Aust N Z J Obstet Gynaecol] 2020 Jun; Vol. 60 (3), pp. 344-349. Date of Electronic Publication: 2019 Sep 11.
DOI: 10.1111/ajo.13046
Abstrakt: Background: Postpartum haemorrhage (PPH) kits containing uterotonics are used on obstetric units for the timely management of PPH. Visible discolouration of ergometrine and ergometrine-oxytocin injections was observed in PPH kits stored in medical refrigerators on the obstetric unit at our hospital.
Aim: To investigate the stability of ergometrine and ergometrine-oxytocin injections in PPH kits under simulated clinical storage conditions and to determine the potency of ampoules quarantined from PPH kits on our obstetric unit.
Material and Methods: Ergometrine and ergometrine-oxytocin injection ampoules were stored exposed to and protected from light at 4°C and room temperature (25°C) for up to three months, and assayed by high-performance liquid chromatography. Stability was based on the time for the ergometrine or oxytocin concentration to fall to 90% of the original concentration (t 90 ). The potency of quarantined discoloured ampoules also was determined.
Results: Ergometrine was stable at both temperatures for >6 months, when stored protected from light in simulated clinical conditions. When exposed to light, ergometrine was stable for approximately 4 days at 25°C and 10 days at 4°C. Discoloured ergometrine and ergometrine-oxytocin injection ampoules were found to be <90% of the nominal concentration.
Conclusion: Stability of ergometrine in PPH kits is largely unaffected by temperature fluctuations (at 4°C and 25°C) over 6 months when protected from light. Ergometrine and ergometrine-oxytocin ampoules should be inspected prior to use and any discoloured ampoules discarded.
(© 2019 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists.)
Databáze: MEDLINE
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