The impact of health symptoms on health-related quality of life in early-stage breast cancer survivors.

Autor: de Ligt KM; Department of Research and Development, Netherlands Comprehensive Cancer Organisation, PO Box 19079, 3501 DB, Utrecht, The Netherlands. k.deligt@iknl.n.; Department of Health Technology and Services Research, Technical Medical Centre, University of Twente, Enschede, The Netherlands. k.deligt@iknl.n., Heins M; NIVEL Netherlands Institute for Health Services Research, Utrecht, The Netherlands., Verloop J; Department of Research and Development, Netherlands Comprehensive Cancer Organisation, PO Box 19079, 3501 DB, Utrecht, The Netherlands., Ezendam NPM; Department of Research and Development, Netherlands Comprehensive Cancer Organisation, PO Box 19079, 3501 DB, Utrecht, The Netherlands.; Department of Medical and Clinical Psychology, Tilburg University, Tilburg, The Netherlands., Smorenburg CH; Department of Medical Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, The Netherlands., Korevaar JC; NIVEL Netherlands Institute for Health Services Research, Utrecht, The Netherlands., Siesling S; Department of Research and Development, Netherlands Comprehensive Cancer Organisation, PO Box 19079, 3501 DB, Utrecht, The Netherlands.; Department of Health Technology and Services Research, Technical Medical Centre, University of Twente, Enschede, The Netherlands.
Jazyk: angličtina
Zdroj: Breast cancer research and treatment [Breast Cancer Res Treat] 2019 Dec; Vol. 178 (3), pp. 703-711. Date of Electronic Publication: 2019 Sep 11.
DOI: 10.1007/s10549-019-05433-3
Abstrakt: Purpose: In breast cancer patients, treatment-related health symptoms can occur that may affect their health-related quality of life (HRQoL). This study aimed to determine the impact of health symptoms on HRQoL in breast cancer patients up to 5 years after diagnosis.
Methods: Females surgically treated for early-stage breast cancer diagnosed between 2012 and 2016 (n = 876) were selected from the Netherlands Cancer Registry and invited for a survey about current health symptoms ('Symptoms and Perceptions questionnaire', SaP) and HRQoL ('EORTC-QLQ-C30'). From the latter, functioning and global health were included. Mean scores were compared to norm population scores (T test). Multivariable linear regression analyses were performed to determine the association between health symptoms and global health and functioning.
Results: 404 patients (46%) responded. The median age was 62.2 ± 10.9 years. Respondents had significantly lower mean scores for role, cognitive, emotional, and social functioning than the general population. The most frequently reported health symptoms were musculoskeletal (including pain/complaints in lower/upper extremities/back/neck; 71%) and central nervous system symptoms (including concentration impairment, dizziness, neuralgia; 66%), and fatigue (63%). While most symptoms affected functioning, irrespective of time since diagnosis, especially fatigue, musculoskeletal, central nervous system, and gastrointestinal symptoms were significantly associated (p < 0.05) with lower functioning.
Conclusions: The majority of health symptoms that occur after breast cancer treatment were associated with lower functioning of patients in daily life. This paper urges healthcare providers to support breast cancer patients in alleviating or coping with health symptoms, even years after end of treatment, to improve their functioning.
Databáze: MEDLINE
Externí odkaz: