[The evaluation of oxidation stress in umbilical blood and lysate of endothelial cells of vessels of umbilical cord of newborns.]

Autor:	Popova IG; The V.N. Gorodkov Ivanovskii institute of maternity and childhood of Minzdrav of Russia, 153045, Ivanovo, Russia., Sitnikova OG; The V.N. Gorodkov Ivanovskii institute of maternity and childhood of Minzdrav of Russia, 153045, Ivanovo, Russia., Nazarov SB; The V.N. Gorodkov Ivanovskii institute of maternity and childhood of Minzdrav of Russia, 153045, Ivanovo, Russia., Kuzmenko GN; The V.N. Gorodkov Ivanovskii institute of maternity and childhood of Minzdrav of Russia, 153045, Ivanovo, Russia., Abramova IV; The Ivanovskaia state medical academy of Minzdrav of Russia, 153012, Ivanovo, Russia., Chasha TV; The V.N. Gorodkov Ivanovskii institute of maternity and childhood of Minzdrav of Russia, 153045, Ivanovo, Russia., Pareishvili VV; The V.N. Gorodkov Ivanovskii institute of maternity and childhood of Minzdrav of Russia, 153045, Ivanovo, Russia.
Jazyk:	ruština
Zdroj:	Klinicheskaia laboratornaia diagnostika [Klin Lab Diagn] 2017; Vol. 62 (5), pp. 274-277.
DOI:	10.18821/0869-2084-2017-62-5-274-277
Abstrakt:	The sampling of newborns (n=28) was examined. Out of them, 18 premature children formed main group (gestation age from 28 to35 weeks, body mass 2067,3±76,7g) and 10 mature children formed comparison group (gestation age from 38 to 41 weeks, body mass 3380,2±57,2g) born from mothers with physiologically occurring pregnancy without extra-genital pathology. In all children, the detection of endothelial cells isolated from umbilical cord vein in mixed umbilical blood and lysate was applied and indices of free radical oxidation of lipids, characterizing oxidizing stress as well and anti-oxidation activity using chemiluminescence technique. The study results demonstrated in premature newborns increasing in umbilical blood of indices of fast flash chemiluminescence (Imax), light sun value (S) and tangent of kinetic curve slope (tga) and also increasing of parameters Imax and tga in lysate of endothelial cells of umbilical cord. Al these occurrences testify in these children development oxidation stress being accompanied by compensation increasing of antioxidant activity. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu