Effects of mechanobiological signaling in bone marrow on skeletal health.

Autor: Curtis KJ; Tissue Mechanics Laboratory, Bioengineering Graduate Program, University of Notre Dame, Notre Dame, Indiana.; Advanced Diagnostics and Therapeutics Initiative, University of Notre Dame, Notre Dame, Indiana., Oberman AG; Tissue Mechanics Laboratory, Bioengineering Graduate Program, University of Notre Dame, Notre Dame, Indiana., Niebur GL; Tissue Mechanics Laboratory, Bioengineering Graduate Program, University of Notre Dame, Notre Dame, Indiana.; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana.; Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, Indiana.
Jazyk: angličtina
Zdroj: Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2020 Jan; Vol. 1460 (1), pp. 11-24. Date of Electronic Publication: 2019 Sep 11.
DOI: 10.1111/nyas.14232
Abstrakt: Bone marrow is a cellular tissue that forms within the pore space and hollow diaphysis of bones. As a tissue, its primary function is to support the hematopoietic progenitor cells that maintain the populations of both erythroid and myeloid lineage cells in the bone marrow, making it an essential element of normal mammalian physiology. However, bone's primary function is load bearing, and deformations induced by external forces are transmitted to the encapsulated marrow. Understanding the effects of these mechanical inputs on marrow function and adaptation requires knowledge of the material behavior of the marrow at multiple scales, the loads that are applied, and the mechanobiology of the cells. This paper reviews the current state of knowledge of each of these factors. Characterization of the marrow mechanical environment and its role in skeletal health and other marrow functions remains incomplete, but research on the topic is increasing, driven by interest in skeletal adaptation and the mechanobiology of cancer metastasis.
(© 2019 New York Academy of Sciences.)
Databáze: MEDLINE
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