| Autor: |
Bessa ASM; Departamento de Ciências Fisiológicas, Universidade Federal de Goiás, Goiânia, GO, 74.690-900, Brazil., Jesus ÉF; Departamento de Ciências Fisiológicas, Universidade Federal de Goiás, Goiânia, GO, 74.690-900, Brazil., Nunes ADC; Departamento de Ciências Fisiológicas, Universidade Federal de Goiás, Goiânia, GO, 74.690-900, Brazil., Pontes CNR; Departamento de Ciências Fisiológicas, Universidade Federal de Goiás, Goiânia, GO, 74.690-900, Brazil., Lacerda IS; Departamento de Ciências Fisiológicas, Universidade Federal de Goiás, Goiânia, GO, 74.690-900, Brazil., Costa JM; Departamento de Ciências Fisiológicas, Universidade Federal de Goiás, Goiânia, GO, 74.690-900, Brazil., Souza EJ; Departamento de Ciências Fisiológicas, Universidade Federal de Goiás, Goiânia, GO, 74.690-900, Brazil., Lino-Júnior RS; Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, GO, 74.690-900, Brazil., Biancardi MF; Departamento de Histologia, Universidade Federal de Goiás, Goiânia, GO, 74.690-900, Brazil., Dos Santos FCA; Departamento de Histologia, Universidade Federal de Goiás, Goiânia, GO, 74.690-900, Brazil., Pedrino GR; Departamento de Ciências Fisiológicas, Universidade Federal de Goiás, Goiânia, GO, 74.690-900, Brazil., Colugnati DB; Departamento de Ciências Fisiológicas, Universidade Federal de Goiás, Goiânia, GO, 74.690-900, Brazil., Mazaro-Costa R; Departamento de Farmacologia, Universidade Federal de Goiás, Goiânia, GO, 74.690-900, Brazil., Mendes EP; Departamento de Ciências Fisiológicas, Universidade Federal de Goiás, Goiânia, GO, 74.690-900, Brazil., Castro CH; Departamento de Ciências Fisiológicas, Universidade Federal de Goiás, Goiânia, GO, 74.690-900, Brazil. castro@ufg.br. |
| Abstrakt: |
The aim of this study was to investigate whether treatment with diminazene aceturate (DIZE), a putative ACE2 activator, or with angiotensin-(1-7) during pregnancy could attenuate the development of cardiovascular dysfunction in the adult offspring of spontaneously hypertensive rats (SHRs). For this, pregnant SHRs received DIZE or Ang-(1-7) throughout gestation. The systolic blood pressure (SBP) was measured in the male offspring from the 6th to16th weeks of age by tail-cuff plethysmography. Thereafter, the left ventricular contractile function and coronary reactivity were evaluated by the Langendorff technique. Samples of the left ventricles (LVs) and kidneys were collected for histology and western blot assay in another batch of adult rat offspring. Maternal treatment with DIZE or Ang-(1-7) during pregnancy attenuated the increase in SBP in adult offspring. In addition, both DIZE and Ang-(1-7) treatments reduced the cardiomyocyte diameter and fibrosis deposition in the LV, and treatment with Ang-(1-7) also reduced the fibrosis deposition in the kidneys. Maternal treatment with DIZE, as well as Ang-(1-7), improved the coronary vasodilation induced by bradykinin in isolated hearts from adult offspring. However, no difference was observed in the contractile function of the LVs of these animals. The expression levels of AT1 and Mas receptors, ACE, ACE2, SOD, and catalase in the LV were not modified by maternal treatment with Ang-(1-7), but this treatment elicited a reduction in AT2 expression. These data show that treatment with DIZE or Ang-(1-7) during gestation promoted beneficial effects of attenuating hypertension and cardiac remodeling in adult offspring. |
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