A Brain Imaging-Based Diagnostic Biomarker for Periodic Catatonia: Preliminary Evidence Using a Bayesian Approach.

Autor:	Foucher JR; ICube - CNRS UMR 7357, Neurophysiology, FMTS, University of Strasbourg, Strasbourg, France, jack.foucher@chru-strasbourg.fr.; CEMNIS - Noninvasive Neuromodulation Center, University Hospital Strasbourg, Strasbourg, France, jack.foucher@chru-strasbourg.fr., de Billy C; ICube - CNRS UMR 7357, Neurophysiology, FMTS, University of Strasbourg, Strasbourg, France.; CEMNIS - Noninvasive Neuromodulation Center, University Hospital Strasbourg, Strasbourg, France., Jeanjean LC; ICube - CNRS UMR 7357, Neurophysiology, FMTS, University of Strasbourg, Strasbourg, France.; CEMNIS - Noninvasive Neuromodulation Center, University Hospital Strasbourg, Strasbourg, France., Obrecht A; CEMNIS - Noninvasive Neuromodulation Center, University Hospital Strasbourg, Strasbourg, France.; Pôle de Psychiatrie, Santé Mentale et Addictologie, University Hospital Strasbourg, Strasbourg, France., Mainberger O; ICube - CNRS UMR 7357, Neurophysiology, FMTS, University of Strasbourg, Strasbourg, France.; CEMNIS - Noninvasive Neuromodulation Center, University Hospital Strasbourg, Strasbourg, France., Clauss JME; Pôle de Psychiatrie, Santé Mentale et Addictologie, University Hospital Strasbourg, Strasbourg, France.; SAGE - CNRS UMR 7363, FMTS, University of Strasbourg, Strasbourg, France., Schorr B; Pôle de Psychiatrie, Santé Mentale et Addictologie, University Hospital Strasbourg, Strasbourg, France.; Physiopathologie et Psychopathologie Cognitive de la Schizophrénie - INSERM 1114, FMTS, University of Strasbourg, Strasbourg, France., Lupu MC; Pôle de Psychiatrie G02, EPSAN, Brumath, France., de Sousa PL; ICube - CNRS UMR 7357, Neurophysiology, FMTS, University of Strasbourg, Strasbourg, France., Lamy J; ICube - CNRS UMR 7357, Neurophysiology, FMTS, University of Strasbourg, Strasbourg, France., Noblet V; ICube - CNRS UMR 7357, Neurophysiology, FMTS, University of Strasbourg, Strasbourg, France., Sauleau EA; Biostatistical Laboratory, iCube - CNRS UMR 7357, University of Strasbourg, Strasbourg, France., Landré L; ICube - CNRS UMR 7357, Neurophysiology, FMTS, University of Strasbourg, Strasbourg, France., Berna F; Pôle de Psychiatrie, Santé Mentale et Addictologie, University Hospital Strasbourg, Strasbourg, France.; Physiopathologie et Psychopathologie Cognitive de la Schizophrénie - INSERM 1114, FMTS, University of Strasbourg, Strasbourg, France.
Jazyk:	angličtina
Zdroj:	Neuropsychobiology [Neuropsychobiology] 2020; Vol. 79 (4-5), pp. 352-365. Date of Electronic Publication: 2019 Sep 10.
DOI:	10.1159/000501830
Abstrakt:	Periodic catatonia (PC) is a psychomotor phenotype with a progressive-remitting course. While it can fit any disorder diagnosis of the schizoaffective spectrum, its core features consist of a mix of hypo- and hyperkinesias resulting in distortions of expressive movements such as grimacing and parakinesias. The replication of cerebral blood flow (CBF) increases in the left supplementary motor area (L-SMA) and lateral premotor cortex (L-LPM) in acute and remitting PC patients indicates that these increases could be used as diagnostic biomarkers. In this proof-of-concept study, 2 different MRI sequences were repeated on 3 separate days to get reliable measurement values of CBF in 9 PC and 26 non-PC patients during different cognitive tasks. Each patient was compared to 37 controls. In L-SMA [-9; +10; +60] and L-LPM [-46; -12; +43], a test was positive if the t value was >2.02 (α < 0.05; two tailed). The measurements had good analytical performance. Regarding the tests, their sensitivities and specificities were significantly different from the chance level on both measures, except for L-SMA sensitivities. When combining all the tests, among regions and methods, sensitivity was 98% (95% credible interval [CI] 76-100%) and specificity 88% (72-97%). Bayesian inferences of its negative predictive values for PC were >95% regardless of the context, while its positive predictive values reached 94% but only when used in combination with clinical criteria. The case-by-case analysis suggests that non-PC patients with neurological motor deficits are at risk to be false positive. (© 2019 S. Karger AG, Basel.)
Databáze:	MEDLINE
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