[The clinical laboratory criteria of infectious complications in primary patients with acute leucosis.]

Autor:	Plotnikova SV; The Bashkirskii` state medical university of Minzdrav of Russia, 450008, Ufa, Russia., Safuanova GS; The Bashkirskii` state medical university of Minzdrav of Russia, 450008, Ufa, Russia., Aznabaeva LF; The Bashkirskii` state medical university of Minzdrav of Russia, 450008, Ufa, Russia., Ryabchikova NR; The Bashkirskii` state medical university of Minzdrav of Russia, 450008, Ufa, Russia.
Jazyk:	ruština
Zdroj:	Klinicheskaia laboratornaia diagnostika [Klin Lab Diagn] 2017; Vol. 62 (6), pp. 342-346.
DOI:	10.18821/0869-2084-2017-62-6-342-346
Abstrakt:	The study was carried out with the purpose of investigating clinical laboratory features of immune reaction in primary patients with acute leucosis and their significance in development of infectious complications. The analysis was applied to indices of immunograms, main anti-inflammatory cytokines - IL-1β, IL-6, IL-8 and FNOα, molecule of inter-cellular adhesion sICAM-1 and also expression of receptors to IgG (CD16, CD64) on cells of macrophage phagocyte component and intracellular content of myeloperoxidase. It is established that development of infectious complications is connected to imbalance of congenital immunity and is characterized by involvement into systemic inflammation anti-inflammatory cytokines FNOα, IL-6, molecule of inter-cellular adhesion sICAM-1 and reduced capacity of neutrophils to phagocytosis conditioned by insufficiency of membrane expression of receptors to IgG - CD16 combined with enzymatic insufficiency. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu