Prebiotics may reduce serum concentrations of C-reactive protein and ghrelin in overweight and obese adults: a systematic review and meta-analysis.

Autor:	da Silva Borges D; D. da Silva Borges is with the Post-Graduate Program in Neuroscience, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC, Brazil., Fernandes R; R. Fernandes is with the Faculty of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil., Thives Mello A; A. Thives Mello is with the Graduate Program in Nutrition, Center of Health Sciences, Federal University of Santa Catarina, Florianópolis, SC, Brazil., da Silva Fontoura E; E. da Silva Fontoura is with the Post-Graduate Program in Nutrition, Center of Health Sciences, Federal University of Santa Catarina, Florianópolis, SC, Brazil., Soares Dos Santos AR; A.R. Soares dos Santos is with the Laboratory of Neurobiology of Pain and Inflammation, Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC, Brazil., Santos de Moraes Trindade EB; E.B.S. de Moraes Trindade is with the Department of Nutrition, Center of Health Sciences, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
Jazyk:	angličtina
Zdroj:	Nutrition reviews [Nutr Rev] 2020 Mar 01; Vol. 78 (3), pp. 235-248.
DOI:	10.1093/nutrit/nuz045
Abstrakt:	Context: Biochemical markers correlate positively with the development and severity of obesity, depression, and anxiety, and can be modulated by changes in intestinal microbiota composition. Objective: A systematic review and meta-analysis was conducted to determine the effects of prebiotics or synbiotics on blood biomarkers of obesity, depression, and anxiety (including: ACTH [adrenocorticotropic hormone], cortisol, leptin, ghrelin, TSH [thyroid-stimulating hormone], PTH [parathyroid hormone], vitamin D, BDNF [brain-derived neurotrophic factor], and PCR [polymerase chain reaction]) in individuals with overweight or obesity. Data Sources: MEDLINE, Web of Science, Scopus, and CENTRAL databases were searched, along with the reference lists of included articles. Authors were contacted for unpublished data. Study Selection: RCT in individuals with overweight or obesity, supplemented with prebiotics or synbiotics, assessing any of the outcomes of interest. Data Extraction: Data were extracted independently by three researchers. Results: Thirteen studies were identified up to March 7, 2018. Regarding outcomes, 1 study assessed leptin, 4 studies assessed ghrelin, and 10 studies assessed CRP (C-reactive protein). Meta-analysis showed reduction in serum concentrations of ghrelin (-37.17 pg/mL; 95%CI = -69.62, -4.73; P = 0.025) and CRP (SMD [standardized mean difference] = -0.31; 95%CI = -0.58, -0.04; P = 0.027) after supplementation of inulin-type fructans. Conclusions: Prebiotics may help regulate blood concentrations of ghrelin and CRP in overweight or obese individuals. (© The Author(s) 2019. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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