Consequences of negative energy balance on follicular development and oocyte quality in primiparous sows†.

Autor:	Costermans NGJ; Human and Animal Physiology, Wageningen University and Research, Wageningen, The Netherlands.; Adaptation Physiology, Wageningen University and Research, Wageningen, The Netherlands., Teerds KJ; Human and Animal Physiology, Wageningen University and Research, Wageningen, The Netherlands., Middelkoop A; Adaptation Physiology, Wageningen University and Research, Wageningen, The Netherlands., Roelen BAJ; Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands., Schoevers EJ; Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands., van Tol HTA; Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands., Laurenssen B; Adaptation Physiology, Wageningen University and Research, Wageningen, The Netherlands., Koopmanschap RE; Adaptation Physiology, Wageningen University and Research, Wageningen, The Netherlands., Zhao Y; Human and Animal Physiology, Wageningen University and Research, Wageningen, The Netherlands., Blokland M; Wageningen Food Safety Research (WFSR), Wageningen University & Research, Akkermaalsbos 2, 6708WB Wageningen, The Netherlands., van Tricht F; Wageningen Food Safety Research (WFSR), Wageningen University & Research, Akkermaalsbos 2, 6708WB Wageningen, The Netherlands., Zak L; TopigsNorsvin Research Center B. V., Beuningen, The Netherlands., Keijer J; Human and Animal Physiology, Wageningen University and Research, Wageningen, The Netherlands., Kemp B; Adaptation Physiology, Wageningen University and Research, Wageningen, The Netherlands., Soede NM; Adaptation Physiology, Wageningen University and Research, Wageningen, The Netherlands.
Jazyk:	angličtina
Zdroj:	Biology of reproduction [Biol Reprod] 2020 Feb 14; Vol. 102 (2), pp. 388-398.
DOI:	10.1093/biolre/ioz175
Abstrakt:	Metabolic demands of modern hybrid sows have increased over the years, which increases the chance that sows enter a substantial negative energy balance (NEB) during lactation. This NEB can influence the development of follicles and oocytes that will give rise to the next litter. To study effects of a lactational NEB on follicular development, we used 36 primiparous sows of which 18 were subjected to feed restriction (3.25 kg/day) and 18 were full-fed (6.5 kg/day) during the last 2 weeks of a 24.1 ± 0.3 day lactation. Feed restriction resulted in a 70% larger lactational body weight loss and 76% higher longissimus dorsi depth loss, but similar amounts of backfat loss compared to the full fed sows. These changes were accompanied by lower plasma insulin-like growth factor 1 (IGF1) and higher plasma creatinine levels in the restricted sows from the last week of lactation onward. Ovaries were collected 48 h after weaning. Restricted sows had a lower average size of the 15 largest follicles (-26%) and cumulus-oocyte complexes showed less expansion after 22 h in vitro maturation (-26%). Less zygotes of restricted sows reached the metaphase stage 24 h after in vitro fertilization and showed a higher incidence of polyspermy (+89%). This shows that feed restriction had severe consequences on oocyte developmental competence. Follicular fluid of restricted sows had lower IGF1 (-56%) and steroid levels (e.g., β-estradiol, progestins, and androgens), which indicated that follicles of restricted sows were less competent to produce steroids and growth factors needed for oocytes to obtain full developmental competence. (© The Author(s) 2019. Published by Oxford University Press on behalf of Society for the Study of Reproduction.)
Databáze:	MEDLINE
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