The NIH Common Fund/Roadmap Epigenomics Program: Successes of a comprehensive consortium.

Autor: Satterlee JS; Division of Neuroscience and Behavior, National Institutes of Health (NIH), 6001 Executive Blvd., Bethesda, MD 20892, USA.; National Institute on Drug Abuse, NIH, 6001 Executive Blvd., Bethesda, MD 20892, USA., Chadwick LH; National Institute on Drug Abuse, NIH, 6001 Executive Blvd., Bethesda, MD 20892, USA., Tyson FL; National Institute of Environmental Health Sciences, NIH, 111 TW Alexander Dr., Durham, NC 27709, USA., McAllister K; National Institute of Environmental Health Sciences, NIH, 111 TW Alexander Dr., Durham, NC 27709, USA., Beaver J; Office of Strategic Coordination, Office of the Director, NIH, 6001 Executive Blvd., Bethesda, MD 20892, USA.; Division of Program Coordination, Planning, and Strategic Initiatives, Office of the Director, NIH, 1 Center Dr., Bethesda, MD 20892, USA., Birnbaum L; National Institute of Environmental Health Sciences, NIH, 111 TW Alexander Dr., Durham, NC 27709, USA., Volkow ND; National Institute on Drug Abuse, NIH, 6001 Executive Blvd., Bethesda, MD 20892, USA., Wilder EL; Office of Strategic Coordination, Office of the Director, NIH, 6001 Executive Blvd., Bethesda, MD 20892, USA.; Division of Program Coordination, Planning, and Strategic Initiatives, Office of the Director, NIH, 1 Center Dr., Bethesda, MD 20892, USA., Anderson JM; Division of Program Coordination, Planning, and Strategic Initiatives, Office of the Director, NIH, 1 Center Dr., Bethesda, MD 20892, USA., Roy AL; Office of Strategic Coordination, Office of the Director, NIH, 6001 Executive Blvd., Bethesda, MD 20892, USA.; Division of Program Coordination, Planning, and Strategic Initiatives, Office of the Director, NIH, 1 Center Dr., Bethesda, MD 20892, USA.
Jazyk: angličtina
Zdroj: Science advances [Sci Adv] 2019 Jul 10; Vol. 5 (7), pp. eaaw6507. Date of Electronic Publication: 2019 Jul 10 (Print Publication: 2019).
DOI: 10.1126/sciadv.aaw6507
Abstrakt: The NIH Roadmap Epigenomics Program was launched to deliver reference epigenomic data from human tissues and cells, develop tools and methods for analyzing the epigenome, discover novel epigenetic marks, develop methods to manipulate the epigenome, and determine epigenetic contributions to diverse human diseases. Here, we comment on the outcomes from this program: the scientific contributions made possible by a consortium approach and the challenges, benefits, and lessons learned from this group science effort.
Databáze: MEDLINE