Epstein-Barr virus infection in gliomas.

Autor: Limam S; Pathology Department, Farhet Hached University Hospital of Sousse, 4000 Sousse, Tunisia., Missaoui N; Research Unit UR14ES17, Medicine Faculty, Sousse University, 4000 Sousse, Tunisia; Faculty of Sciences and Techniques of Sidi Bouzid, Kairouan University, Tunisia. Electronic address: missaouinabiha@live.fr., Mestiri S; Pathology Department, Farhet Hached University Hospital of Sousse, 4000 Sousse, Tunisia., Yacoubi MT; Pathology Department, Farhet Hached University Hospital of Sousse, 4000 Sousse, Tunisia., Krifa H; Department of Neurosurgery, Sahloul University Hospital, Sousse, Tunisia., Selmi B; Laboratory of Bioresources, Integrative Biology and Exploiting, Biotechnology Higher Institute, Monastir University, 5000 Monastir, Tunisia., Mokni M; Pathology Department, Farhet Hached University Hospital of Sousse, 4000 Sousse, Tunisia.
Jazyk: angličtina
Zdroj: Current research in translational medicine [Curr Res Transl Med] 2019 Nov; Vol. 67 (4), pp. 129-133. Date of Electronic Publication: 2019 Sep 06.
DOI: 10.1016/j.retram.2019.06.002
Abstrakt: Purpose of the Study: Epstein-Barr virus (EBV) has been involved in the development of some tumors, including Burkitt's lymphoma and Hodgkin's lymphoma. However, its potential role in glioma tumorigenesis remains debated. In this study, we investigated the EBV infection in gliomas from Tunisian patients.
Patients and Methods: We conducted a retrospective study of 112 gliomas on archival material. The EBV DNA sequence was analyzed by polymerase chain reaction (PCR). Latent membrane protein 1 (LMP1) was detected by immunohistochemistry. In situ hybridization was used to detect EBV encoded small RNA (EBER). Clinicopathological features were recorded. Survival analysis was carried out using the Kaplan-Meier method and the Log-Rank test to compare EBV-positive and EBV-negative patients.
Results: Overall, there were twenty-four EBV-positive gliomas (21.4%). EBV DNA was identified in 24 cases. LMP1 and EBER were detected in four EBV DNA-positive cases. All EBV-positive cases were glioblastomas multiforme (GBM). Median overall survival and recurrence-free survival of EBV-negative patients were better than those of EBV-positive patients (Log Rank p =  0.006).
Conclusion: Altogether, these findings support the occurrence of EBV infection in Tunisian GBM. Furthermore, when compared to EBV-negative tumors, EBV infection seems to be associated with the worst patient prognosis. Advanced molecular studies are recommended to confirm these results and to shed further light on the potential role of EBV in these devastating tumors.
(Copyright © 2019. Published by Elsevier Masson SAS.)
Databáze: MEDLINE
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