A 3D printed chitosan-pectin hydrogel wound dressing for lidocaine hydrochloride delivery.

Autor: Long J; Drug Delivery Research Group, School of Science, Faculty of Health and Environmental Sciences, Auckland University of Technology, Level 5, WS building, 34 St Paul St, Auckland 1010, New Zealand., Etxeberria AE; Drug Delivery Research Group, School of Science, Faculty of Health and Environmental Sciences, Auckland University of Technology, Level 5, WS building, 34 St Paul St, Auckland 1010, New Zealand; BIOMAT Research Group, University of the Basque Country (UPV/EHU), Department of Chemical and Environmental Engineering, Engineering College of Gipuzkoa, Donostia-San Sebastian, Spain., Nand AV; Health and Community, and Environmental and Animal Sciences Network, Unitec Institute of Technology, 139 Carrington Rd, Mount Albert, Auckland 1025, New Zealand., Bunt CR; Department of Agricultural Sciences, Faculty of Agriculture and Life Sciences, Lincoln University, Canterbury, New Zealand., Ray S; MBIE Biocide Toolbox and (NZ)Product Accelerator programme, School of Chemical Sciences, University of Auckland, Auckland, New Zealand., Seyfoddin A; Drug Delivery Research Group, School of Science, Faculty of Health and Environmental Sciences, Auckland University of Technology, Level 5, WS building, 34 St Paul St, Auckland 1010, New Zealand; School of Interprofessional Health Studies, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New Zealand. Electronic address: ali.seyfoddin@aut.ac.nz.
Jazyk: angličtina
Zdroj: Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2019 Nov; Vol. 104, pp. 109873. Date of Electronic Publication: 2019 Jun 08.
DOI: 10.1016/j.msec.2019.109873
Abstrakt: A chitosan-pectin (CS-PEC) biopolymeric hydrogel wound dressing was investigated for lidocaine delivery. Here we demonstrate for the first time the feasibility of three-dimensional (3D) printed CS-PEC hydrogel incorporating the local anaesthetic drug lidocaine hydrochloride (LDC) as a potential wound dressing candidate. The hydrogels were prepared by physical crosslinking of CS and PEC polysaccharides. The scaffolds were printed using an extrusion-based 3D printer using a mechanical positive displacement dispensing system followed by lyophilisation. The 3D printed hydrogels showed good printability, dimensional integrity and self-adhesion to skin. The high swelling ratio and water absorption of 3D printed hydrogels indicated suitability for absorbing exudates and maintaining a moist wound healing environment. Fourier transform infrared (FTIR) spectroscopy results indicated that the CS-PEC hydrogel was formed by hydrogen bonds. Incorporation of LDC in the hydrogel did not interfere with its functional stability. In vitro drug release studies of LDC over 6 h fitted the Korsmeyer-Peppas model. This work demonstrates the possibility of a 3D printed hydrogel as a suitable candidate for wound dressings.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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