Modulatory effect of photobiomodulation on stem cell epigenetic memory: a highlight on differentiation capacity.

Autor: Zamani ARN; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Saberianpour S; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Geranmayeh MH; Neuroscience Research Center, Imam Reza Medical Center, Tabriz University of Medical Sciences, Tabriz, Iran., Bani F; Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran., Haghighi L; Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran., Rahbarghazi R; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Rezarahbardvm@gmail.com.; Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Rezarahbardvm@gmail.com.
Jazyk: angličtina
Zdroj: Lasers in medical science [Lasers Med Sci] 2020 Mar; Vol. 35 (2), pp. 299-306. Date of Electronic Publication: 2019 Sep 07.
DOI: 10.1007/s10103-019-02873-7
Abstrakt: Differentiation potential of stem cells into various lineages makes these cells as promising sources to treat multiple diseases. In this regard, the use of different strategies and protocols to increase differentiation capacity is highly demanded. Low-level laser therapy, a relatively noninvasive technique, has the capacity to accelerate the healing of numerous injuries and a portion of restorative capacity could be correlated with the stem cell activation and differentiation. Several mechanisms have been diagnosed to participate in orientation of stem cells to functional mature cells. Among them, the status of DNA methylation orchestrates the maintenance of tissue-specific gene expression during the differentiation procedure. DNA methylation is a momentous event in embryogenesis and functional maturation. This review article highlighted the potency of laser irradiation (low-level intensities) in the differentiation of stem cells by modulation of methylation. The analysis of these modalities could help us to understand the underlying mechanisms participating in the therapeutic effects of photobiomodulation.
Databáze: MEDLINE
Externí odkaz: