Egg White Hydrolysate: A new putative agent to prevent vascular dysfunction in rats following long-term exposure to aluminum.

Autor: Martinez CS; Cardiovascular Physiology Research Group, Universidade Federal do Pampa, BR 472 - Km 592 - PO box 118, 97500-970, Uruguaiana, Rio Grande do Sul, Brazil. Electronic address: giuliapecanha@unipampa.edu.br., Piagette JT; Cardiovascular Physiology Research Group, Universidade Federal do Pampa, BR 472 - Km 592 - PO box 118, 97500-970, Uruguaiana, Rio Grande do Sul, Brazil., Escobar AG; Cardiovascular Physiology Research Group, Universidade Federal do Pampa, BR 472 - Km 592 - PO box 118, 97500-970, Uruguaiana, Rio Grande do Sul, Brazil., Martín Á; Department of Ciencias Básicas de la Salud, Universidad Rey Juan Carlos, Avda. de Atenas s/n, Alcorcón, Spain; Instituto de Investigación Hospital La Paz, Spain and Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Cardiovasculares, Madrid, Spain., Palacios R; Department of Ciencias Básicas de la Salud, Universidad Rey Juan Carlos, Avda. de Atenas s/n, Alcorcón, Spain; Instituto de Investigación Hospital La Paz, Spain and Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Cardiovasculares, Madrid, Spain., Peçanha FM; Cardiovascular Physiology Research Group, Universidade Federal do Pampa, BR 472 - Km 592 - PO box 118, 97500-970, Uruguaiana, Rio Grande do Sul, Brazil., Vassallo DV; Departments of Physiological Sciences, Universidade Federal do Espírito Santo and School of Medicine of Santa Casa de Misericórdia (EMESCAM), Av. Marechal Campos 1468, 29040-090, Vitória, Espírito Santo, Brazil., Exley C; The Birchall Centre, Lennard-Jones Laboratories, Keele University, Staffordshire, ST5 5BG, UK., Alonso MJ; Department of Ciencias Básicas de la Salud, Universidad Rey Juan Carlos, Avda. de Atenas s/n, Alcorcón, Spain; Instituto de Investigación Hospital La Paz, Spain and Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Cardiovasculares, Madrid, Spain., Salaices M; Instituto de Investigación Hospital La Paz, Spain and Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Cardiovasculares, Madrid, Spain; Department of Pharmacology, Universidad Autónoma de Madrid, C/ Arzobispo Morcillo 4, 28029, Madrid, Spain., Miguel M; Instituto de Investigación, Hospital La Paz, Spain; Bioactivity and Food Analysis Laboratory, Instituto de Investigación en Ciencias de la Alimentación, Nicolás Cabrera, 9, Campus Universitario de Cantoblanco, Madrid, Spain. Electronic address: marta.miguel@csic.es., Wiggers GA; Cardiovascular Physiology Research Group, Universidade Federal do Pampa, BR 472 - Km 592 - PO box 118, 97500-970, Uruguaiana, Rio Grande do Sul, Brazil.
Jazyk: angličtina
Zdroj: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2019 Nov; Vol. 133, pp. 110799. Date of Electronic Publication: 2019 Sep 05.
DOI: 10.1016/j.fct.2019.110799
Abstrakt: Aluminum (Al) is toxic for humans and animals. Here, we have tested the potential for Egg White Hydrolysate (EWH) to protect against cardiovascular changes in rats exposed to both high and low dietary levels of Al. Indeed, EWH has been previously shown to improve cardio metabolic dysfunctions induced by chronic exposure to heavy metals. Male Wistar rats received orally: Group 1) Low aluminum level (AlCl 3 at a dose of 8.3 mg/kg b.w. during 60 days) with or without EWH treatment (1 g/kg/day); Group 2) High aluminum level (AlCl 3 at a dose of 100 mg/kg b.w. during 42 days) with or without EWH treatment. After Al treatment, rats co-treated with EWH did not show vascular dysfunction or increased blood pressure as was observed in non EWH-cotreated animals. Indeed, co-treatment with EWH prevented the following effects observed in both aorta and mesenteric arteries: the increased vascular responses to phenylephrine (Phe), the decreased ACh-induced relaxation, the reduction on endothelial modulation of vasoconstrictor responses and the nitric oxide bioavailability, as well as the increased reactive oxygen species production from NAD(P)H oxidase. Altogether, our results suggest that EWH could be used as a protective agent against the harmful vascular effects after long term exposure to Al.
(Copyright © 2019. Published by Elsevier Ltd.)
Databáze: MEDLINE
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