| Autor: |
Trevisan A; Department of Cardiac Thoracic Vascular Sciences and Public Health, Unit of Preventive Medicine and Risk Assessment, University of Padova, Padova, Italy., Frasson C; Department of Cardiac Thoracic Vascular Sciences and Public Health, Unit of Preventive Medicine and Risk Assessment, University of Padova, Padova, Italy., De Nuzzo D; Department of Cardiac Thoracic Vascular Sciences and Public Health, Unit of Preventive Medicine and Risk Assessment, University of Padova, Padova, Italy., Nicolli A; Department of Cardiac Thoracic Vascular Sciences and Public Health, Unit of Preventive Medicine and Risk Assessment, University of Padova, Padova, Italy., Scapellato ML; Department of Cardiac Thoracic Vascular Sciences and Public Health, Unit of Preventive Medicine and Risk Assessment, University of Padova, Padova, Italy. |
| Jazyk: |
angličtina |
| Zdroj: |
Human vaccines & immunotherapeutics [Hum Vaccin Immunother] 2020; Vol. 16 (2), pp. 460-464. Date of Electronic Publication: 2019 Sep 05. |
| DOI: |
10.1080/21645515.2019.1656483 |
| Abstrakt: |
Hepatitis B vaccination (three-dose series) induces long-term immunity, but it is not uncommon to find antibody levels below 10 IU/L long after vaccination. However, the majority of the subjects with low antibody levels have a prompt response to a booster dose. A population of 10,294 students at Padua University Medical School, who were subjected to hepatitis B vaccination during infancy or adolescence according to the law, was tested for the presence of anti-HBs, usually during the first year of matriculation. Among the students offered a booster dose, 1,030 were vaccinated, and the antibody titre was re-tested. The present research provides further evidence from a larger number of students (1,030) that an anti-HB level higher than 2 IU/L is predictive of a prompt response to a booster. There are also differences related to sex. The results clearly confirm that an antibody titre equal to or greater than 2 IU/L is enough to prompt a response after a booster dose, even several years after the initial vaccination cycle, and to predict effective immune protection. The length of the interval between the booster/post-booster analyses increases the probability of finding a low response to the booster; furthermore, females show a more rapid response to the booster than males. The importance for healthcare workers of measuring the antibody titre four weeks after a booster is highlighted, and the results suggest that females have a better response than males to booster vaccination. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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