Piper sarmentosum Leaves Aqueous Extract Attenuates Vascular Endothelial Dysfunction in Spontaneously Hypertensive Rats.

Autor: Hashim Fauzy F; Department of Basic Medical Sciences, International Islamic University Malaysia, Kuantan 25200, Malaysia., Mohd Zainudin M; Department of Basic Medical Sciences, International Islamic University Malaysia, Kuantan 25200, Malaysia., Ismawi HR; Department of Basic Medical Sciences, International Islamic University Malaysia, Kuantan 25200, Malaysia., Elshami TFT; Department of Basic Medical Sciences, International Islamic University Malaysia, Kuantan 25200, Malaysia.
Jazyk: angličtina
Zdroj: Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2019 Aug 14; Vol. 2019, pp. 7198592. Date of Electronic Publication: 2019 Aug 14 (Print Publication: 2019).
DOI: 10.1155/2019/7198592
Abstrakt: Piper sarmentosum is a tropical plant in Southeast Asia known for its traditional use in curing various ailments including hypertension. Previous research works have provided evidence for the herb's antihypertensive property. However, the exact mechanisms involved are still in question. The present study investigated the effects of Piper sarmentosum leaves aqueous extract (PSAE) treatment on vascular endothelin system in spontaneously hypertensive rats (SHRs). Four groups of SHRs were treated for 28 consecutive days, with negative and positive control groups receiving distilled water and 3 mg/kg perindopril, respectively. Another two groups are the treatment groups, which received PSAE and combination of 1.5 mg/kg perindopril and PSAE. Weekly measurements of blood pressure showed that PSAE significantly reduced the systolic, diastolic, and mean arterial pressures ( P < 0.05) of the rats. PSAE also increased mesenteric artery nitric oxide (NO) level ( P < 0.05) and reduced endothelin-1 (ET-1) level ( P < 0.05) in the treatment groups. Our results demonstrate that oral administration of PSAE reduced blood pressure in SHRs by reducing the ET-1 level while increasing NO production.
Competing Interests: The authors declare that there are no conflicts of interest regarding the publication of this article.
Databáze: MEDLINE
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