Pallidal low-frequency activity in dystonia after cessation of long-term deep brain stimulation.

Autor: Scheller U; Charité, Universitätsmedizin Berlin, Campus Mitte, Movement Disorders and Neuromodulation Unit, Department of Neurology, Berlin, Germany., Lofredi R; Charité, Universitätsmedizin Berlin, Campus Mitte, Movement Disorders and Neuromodulation Unit, Department of Neurology, Berlin, Germany., van Wijk BCM; Charité, Universitätsmedizin Berlin, Campus Mitte, Movement Disorders and Neuromodulation Unit, Department of Neurology, Berlin, Germany.; Integrative Model-Based Cognitive Neuroscience Research Unit, Department of Psychology, University of Amsterdam, Amsterdam, the Netherlands.; Wellcome Centre for Human Neuroimaging, University College London Institute of Neurology, London, UK., Saryyeva A; Medizinische Hochschule Hannover, Department of Neurosurgery, Hannover, Germany., Krauss JK; Medizinische Hochschule Hannover, Department of Neurosurgery, Hannover, Germany., Schneider GH; Charité, Universitätsmedizin Berlin, Campus Mitte, Department of Neurosurgery, Berlin, Germany., Kroneberg D; Charité, Universitätsmedizin Berlin, Campus Mitte, Movement Disorders and Neuromodulation Unit, Department of Neurology, Berlin, Germany., Krause P; Charité, Universitätsmedizin Berlin, Campus Mitte, Movement Disorders and Neuromodulation Unit, Department of Neurology, Berlin, Germany., Neumann WJ; Charité, Universitätsmedizin Berlin, Campus Mitte, Movement Disorders and Neuromodulation Unit, Department of Neurology, Berlin, Germany., Kühn AA; Charité, Universitätsmedizin Berlin, Campus Mitte, Movement Disorders and Neuromodulation Unit, Department of Neurology, Berlin, Germany.; NeuroCure, Universitätsmedizin Berlin, Berlin, Germany.
Jazyk: angličtina
Zdroj: Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2019 Nov; Vol. 34 (11), pp. 1734-1739. Date of Electronic Publication: 2019 Sep 04.
DOI: 10.1002/mds.27838
Abstrakt: Objective: This study investigates the association between pallidal low-frequency activity and motor sign severity in dystonia after chronic deep brain stimulation for several months.
Methods: Local field potentials were recorded in 9 dystonia patients at 5 timepoints (T1-T5) during an OFF-stimulation period of 5 to 7 hours in parallel with clinical assessment using Burke-Fahn-Marsden Dystonia Rating Scale. A linear mixed effects model was used to investigate the potential association of motor signs with local field potential activity in the low frequency (3-12 Hz) and beta range (13-30 Hz).
Results: A significant association of Burke-Fahn-Marsden Dystonia Rating Scale scores with low-frequency activity (3-12 Hz; b = 4.4; standard error = 1.5, degrees of freedom = 43, P = 0.006, 95% confidence interval, 1.3-7.5), but not beta activity (13-30 Hz) was revealed within participants across timepoints.
Conclusion: Low-frequency activity is associated with dystonic motor sign severity, even months after chronic deep brain stimulation. Our findings corroborate the pathophysiological role of low-frequency activity in dystonia and highlight the potential utility as a biomarker for adaptive neuromodulation. © 2019 International Parkinson and Movement Disorder Society.
(© 2019 International Parkinson and Movement Disorder Society.)
Databáze: MEDLINE
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