Differences in omentin-1 levels in term newborns according to birth weight.

Autor: Hernández-Rodríguez CE; Universidad Autónoma de Nuevo León, Facultad de Medicina y Hospital Universitario 'Dr. Jose E. Gonzalez', Department of Pediatrics, Monterrey, Mexico., Estrada-Zúñiga CM; Universidad Autónoma de Nuevo León, Facultad de Medicina y Hospital Universitario 'Dr. Jose E. Gonzalez', Department of Pediatrics, Monterrey, Mexico., De la O-Cavazos ME; Universidad Autónoma de Nuevo León, Facultad de Medicina y Hospital Universitario 'Dr. Jose E. Gonzalez', Department of Pediatrics, Monterrey, Mexico., García-Rodríguez F; Universidad Autónoma de Nuevo León, Facultad de Medicina y Hospital Universitario 'Dr. Jose E. Gonzalez', Department of Pediatrics, Monterrey, Mexico., Rodríguez-Balderrama I; Universidad Autónoma de Nuevo León, Facultad de Medicina y Hospital Universitario 'Dr. Jose E. Gonzalez', Department of Pediatrics, Monterrey, Mexico., Zapata-Castilleja CA; Universidad Autónoma de Nuevo León, Facultad de Medicina y Hospital Universitario 'Dr. Jose E. Gonzalez', Department of Pediatrics, Monterrey, Mexico., Treviño-Garza C; Universidad Autónoma de Nuevo León, Facultad de Medicina y Hospital Universitario 'Dr. Jose E. Gonzalez', Department of Pediatrics, Monterrey, Mexico. Electronic address: cotrevin@hotmail.com.
Jazyk: angličtina
Zdroj: Early human development [Early Hum Dev] 2019 Dec; Vol. 139, pp. 104842. Date of Electronic Publication: 2019 Aug 30.
DOI: 10.1016/j.earlhumdev.2019.104842
Abstrakt: Background: Adipokines are produced by adipose tissue and are involved in metabolic processes. Omentin-1 is an adipokine that has been shown in vitro to possibly be involved in insulin sensitivity modulation. The prenatal stage is a crucial period for development of metabolic diseases in the long term, therefore, small (SGA) and large (LGA) for gestational age newborns have an increased risk of type 2 diabetes and metabolic syndrome later in life.
Aims: To evaluate the differences in omentin-1 concentrations in umbilical cord blood from healthy term newborns according to birth weight and explore the association between omentin-1 and anthropometry, glucose, insulin and insulin sensitivity.
Study Design: This was a secondary analysis of stored umbilical cord blood of term newborns.
Subjects: Newborns classified according to birth weight as SGA (n = 30), adequate for gestational age (AGA) (n = 12) and LGA (n = 34).
Outcome Measures: An analysis of omentin-1, glucose and insulin were performed.
Results: Differences were found in serum omentin-1 levels (ng/mL) between SGA 328.17 ± 108.04, AGA 253.05 ± 98.25 and LGA 250.91 ± 100.48 (p = 0.009). In the linear regression analysis, the independent variables HOMA-IR, QUICK-I and FGIR were predictors of serum omentin-1 levels (r = 0.175, p = 0.003).
Conclusions: Omentin-1 cord blood levels have a differentiated behavior according to weight for gestational age with LGA newborns having lower levels and SGA newborns higher levels. HOMA-IR, QUICK-I and FGIR weakly predicted omentin-1 in cord blood, suggesting that omentin-1 possibly has an implication in insulin sensitivity since birth.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: