Chemodiversity and Antiproliferative Activity of the Essential Oil of Schinus molle Growing in Jordan.

Autor: Aboalhaija NH; Department of Pharmaceutical Sciences, School of Pharmacy, The University of Jordan, Queen Rania Al Abdallah Street, 11942, Amman, Jordan., Awwad O; Department of Clinical Pharmacy and Biopharmaceutics, School of Pharmacy, The University of Jordan, Queen Rania Al Abdallah Street, 11942, Amman, Jordan., Khalil E; Department of Pharmaceutics and Pharmaceutical Technology, School of Pharmacy, The University of Jordan, Queen Rania Al Abdallah Street, 11942, Amman, Jordan., Abbassi R; Department of Clinical Pharmacy and Biopharmaceutics, School of Pharmacy, The University of Jordan, Queen Rania Al Abdallah Street, 11942, Amman, Jordan., Abaza IF; Department of Pharmaceutical Sciences, School of Pharmacy, The University of Jordan, Queen Rania Al Abdallah Street, 11942, Amman, Jordan., Afifi FU; Department of Pharmaceutical Sciences, School of Pharmacy, The University of Jordan, Queen Rania Al Abdallah Street, 11942, Amman, Jordan.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2019 Nov; Vol. 16 (11), pp. e1900388. Date of Electronic Publication: 2019 Oct 29.
DOI: 10.1002/cbdv.201900388
Abstrakt: The leaves and unripe and fully-grown fruits of Schinus molle were collected from three geographical regions of Jordan: Amman (the Mediterranean), Madaba (Irano-Turanean), and Sahab (Saharo-Arabian). The hydrodistilled volatile oils of fresh and dried leaves and fruits were analyzed by gas chromatography-mass spectrometry (GC/MS). The actual composition of the emitted volatiles was determined using Solid Phase Micro-Extraction (SPME). α- and β-Phellandrenes were the major components in all the analyzed samples. Quantitative differences were observed in the obtained essential oils (0.62-5.25 %). Additionally, cluster analysis was performed. Biologically, the antiproliferative activity of the essential oil, ethanol, and water extracts of the fruits and leaves was screened on Caco2, HCT116, MCF7, and T47D cell lines. The essential oil and ethanol extracts exhibited a dose-dependent inhibition of cell growth with IC 50 ranging between 21 and 65 μg/mL. The water extract did not exhibit any antiproliferative activity against the investigated cell lines.
(© 2019 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
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