Resveratrol-mediated glycemic regulation is blunted by curcumin and is associated to modulation of gut microbiota.

Autor: Sreng N; Institut National de la Santé et de la Recherche Médicale (INSERM), Toulouse, France; Université Paul Sabatier (UPS), Unité Mixte de Recherche (UMR) 1048, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Team 2: 'Intestinal Risk Factors, Diabetes, Dyslipidemia, Heart Failure', F-31432 Toulouse Cedex 4, France; Aix Marseille Univ, INSERM, INRA, C2VN, Marseille, France., Champion S; IMBE-UMR CNRS 7263/IRD 237, Mutagenèse Environnementale, Faculté de Pharmacie, Aix-Marseille Université, 27 boulevard Jean Moulin, 13385, Marseille, France., Martin JC; Aix Marseille Univ, INSERM, INRA, C2VN, Marseille, France., Khelaifia S; Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM 63, CNRS 7278, L'Institut de Recherche pour le Développement 198, Inserm 1095, Institut Hospitalo-Universitaire Méditerranée-Infection, Faculté de Médecine, Aix-Marseille Université, 27 Boulevard Jean Moulin, 13385 Marseille Cedex, 5, France., Christensen JE; Institut National de la Santé et de la Recherche Médicale (INSERM), Toulouse, France; Université Paul Sabatier (UPS), Unité Mixte de Recherche (UMR) 1048, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Team 2: 'Intestinal Risk Factors, Diabetes, Dyslipidemia, Heart Failure', F-31432 Toulouse Cedex 4, France; VAIOMER SAS, 516 Rue Pierre et Marie Curie, 31670 Labège, France., Padmanabhan R; Institut National de la Santé et de la Recherche Médicale (INSERM), Toulouse, France; Université Paul Sabatier (UPS), Unité Mixte de Recherche (UMR) 1048, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Team 2: 'Intestinal Risk Factors, Diabetes, Dyslipidemia, Heart Failure', F-31432 Toulouse Cedex 4, France., Azalbert V; Institut National de la Santé et de la Recherche Médicale (INSERM), Toulouse, France; Université Paul Sabatier (UPS), Unité Mixte de Recherche (UMR) 1048, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Team 2: 'Intestinal Risk Factors, Diabetes, Dyslipidemia, Heart Failure', F-31432 Toulouse Cedex 4, France., Blasco-Baque V; Institut National de la Santé et de la Recherche Médicale (INSERM), Toulouse, France; Université Paul Sabatier (UPS), Unité Mixte de Recherche (UMR) 1048, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Team 2: 'Intestinal Risk Factors, Diabetes, Dyslipidemia, Heart Failure', F-31432 Toulouse Cedex 4, France., Loubieres P; Institut National de la Santé et de la Recherche Médicale (INSERM), Toulouse, France; Université Paul Sabatier (UPS), Unité Mixte de Recherche (UMR) 1048, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Team 2: 'Intestinal Risk Factors, Diabetes, Dyslipidemia, Heart Failure', F-31432 Toulouse Cedex 4, France., Pechere L; Laboratoire YVERY sarl, 134 rue Edmond Rostand, 13008 Marseille, France., Landrier JF; Aix Marseille Univ, INSERM, INRA, C2VN, Marseille, France., Burcelin R; Institut National de la Santé et de la Recherche Médicale (INSERM), Toulouse, France; Université Paul Sabatier (UPS), Unité Mixte de Recherche (UMR) 1048, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Team 2: 'Intestinal Risk Factors, Diabetes, Dyslipidemia, Heart Failure', F-31432 Toulouse Cedex 4, France. Electronic address: remy.burcelin@inserm.fr., Sérée E; Aix Marseille Univ, INSERM, INRA, C2VN, Marseille, France. Electronic address: seree.eric@gmail.com.
Jazyk: angličtina
Zdroj: The Journal of nutritional biochemistry [J Nutr Biochem] 2019 Oct; Vol. 72, pp. 108218. Date of Electronic Publication: 2019 Jul 30.
DOI: 10.1016/j.jnutbio.2019.108218
Abstrakt: The polyphenols resveratrol (RSV) and curcumin (Cur) are phytoalexines and natural antibiotics with numerous pharmacological functions and metabolic impacts. Recent evidences show a broad control of gut microbiota by polyphenols which could influence glycemic regulation. The aim of this work is to estimate the respective effect of RSV and Cur alone or in association on the control of glycemia and on gut microbiota. A 5-week chronic treatment of hyperglycemic mice with RSV and/or Cur resulted in a differential effect on glucose tolerance test and modified gut microbiome. We precisely identified groups of bacteria representing a specific signature of the glycemic effect of RSV. Inferred metagenomic analysis and metabolic pathway prediction showed that the sulfur and branched-chain amino-acid (BCAA) metabolic activities are tightly correlated with the efficacy of RSV for the control of glycaemia. The impact on BCAA metabolism was further validated by serum metabolomics analysis. Altogether, we show that polyphenols specifically impact gut microbiota and corresponding metabolic functions which could be responsible for their therapeutic role.
(Copyright © 2019. Published by Elsevier Inc.)
Databáze: MEDLINE
Externí odkaz: