сWnt signaling modulation results in a change of the colony architecture in a hydrozoan.

Autor: Bagaeva TS; Department of Embryology, Faculty of Biology, Lomonosov Moscow State University, Leninskiye gory 1/12, Moscow, 119234, Russia; Department for Molecular Evolution and Development, Centre of Organismal Systems Biology, University of Vienna, Althanstraße 14, Vienna, A-1090, Austria., Kupaeva DM; Department of Embryology, Faculty of Biology, Lomonosov Moscow State University, Leninskiye gory 1/12, Moscow, 119234, Russia., Vetrova AA; Department of Embryology, Faculty of Biology, Lomonosov Moscow State University, Leninskiye gory 1/12, Moscow, 119234, Russia., Kosevich IA; Laboratory of Animal Development, Department of Invertebrate Zoology, Faculty of Biology, Lomonosov Moscow State University, Leninskiye gory 1/12, Moscow, 119234, Russia., Kraus YA; Department of Evolutionary Biology, Faculty of Biology, Lomonosov Moscow State University, Leninskiye gory 1/12, Moscow, 119234, Russia; Laboratory of Morphogenesis Evolution, Koltzov Institute of Developmental Biology RAS, Vavilova 26, Moscow, 119334, Russia., Kremnyov SV; Department of Embryology, Faculty of Biology, Lomonosov Moscow State University, Leninskiye gory 1/12, Moscow, 119234, Russia; Laboratory of Morphogenesis Evolution, Koltzov Institute of Developmental Biology RAS, Vavilova 26, Moscow, 119334, Russia. Electronic address: s.kremnyov@gmail.com.
Jazyk: angličtina
Zdroj: Developmental biology [Dev Biol] 2019 Dec 15; Vol. 456 (2), pp. 145-153. Date of Electronic Publication: 2019 Aug 29.
DOI: 10.1016/j.ydbio.2019.08.019
Abstrakt: At the polyp stage, most hydrozoan cnidarians form highly elaborate colonies with a variety of branching patterns, which makes them excellent models for studying the evolutionary mechanisms of body plan diversification. At the same time, molecular mechanisms underlying the robust patterning of the architecturally complex hydrozoan colonies remain unexplored. Using non-model hydrozoan Dynamena pumila we showed that the key components of the Wnt/β-catenin (cWnt) pathway (β-catenin, TCF) and the cWnt-responsive gene, brachyury 2, are involved in specification and patterning of the developing colony shoots. Strikingly, pharmacological modulation of the cWnt pathway leads to radical modification of the monopodially branching colony of Dynamena which acquire branching patterns typical for colonies of other hydrozoan species. Our results suggest that modulation of the cWnt signaling is the driving force promoting the evolution of the vast variety of the body plans in hydrozoan colonies and offer an intriguing possibility that the involvement of the cWnt pathway in the regulation of branching morphogenesis might represent an ancestral feature predating the cnidarian-bilaterian split.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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