Significant Value of 11 C-Acetate and 18 F-Fluorodeoxyglucose PET/Computed Tomography on 90 Y Microsphere Radioembolization for Hepatocellular Carcinoma.

Autor:	Ho CL; Department of Nuclear Medicine & PET, Hong Kong Sanatorium & Hospital, 2 Village Road, Happy Valley, Hong Kong, China. Electronic address: garrettho@hksh.com., Chen S; Department of Nuclear Medicine & PET, Hong Kong Sanatorium & Hospital, 2 Village Road, Happy Valley, Hong Kong, China; Medical Physics & Research Department, Hong Kong Sanatorium & Hospital, 2 Village Road, Happy Valley, Hong Kong, China., Cheung SK; Department of Nuclear Medicine & PET, Hong Kong Sanatorium & Hospital, 2 Village Road, Happy Valley, Hong Kong, China., Leung TWT; Comprehensive Oncology Center, Hong Kong Sanatorium & Hospital, 2 Village Road, Happy Valley, Hong Kong, China. Electronic address: Thomas.WT.Leung@hksh.com.
Jazyk:	angličtina
Zdroj:	PET clinics [PET Clin] 2019 Oct; Vol. 14 (4), pp. 459-467. Date of Electronic Publication: 2019 Jul 31.
DOI:	10.1016/j.cpet.2019.06.005
Abstrakt:	Pretreatment dual-tracer ( 18 F-fluorodeoxyglucose and 11 C-acetate) PET/computed tomography (CT) has potential to predict treatment response for 90 Y microsphere radioembolization (RE) in patients with inoperable hepatocellular carcinoma (HCC). Patients with 11 C-acetate-avid HCC have a better response to 90 Y microsphere RE, and possibly better survival. Pretreatment dual-tracer PET/CT has a significant theranostic value on 90 Y microsphere RE in determining target tumor dose for HCCs with different cellular differentiation, metabolic tumor volume, and functioning liver volume, and can be used to prescribe individual injected activity of 90 Y microspheres. (Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu